Extracellular matrix-based intracortical microelectrodes:Toward a microfabricated neural interface based on natural materials  

作　　者：Wen Shen Lohitash Karumbaiah Xi Liu Tarun Saxena Shuodan Chen Radhika Patkar Ravi V.Bellamkonda Mark G.Allen 

机构地区：[1]Institute for Electronics and Nanotechnology,Georgia Institute of Technology,Atlanta,GA 30332,USA [2]Wallace H Coulter Department of Biomedical Engineering,Georgia Institute of Technology&Emory School of Medicine,Atlanta,GA 30332,USA [3]George W.Woodruff School of Mechanical Engineering,Georgia Institute of Technology,Atlanta,GA 30332,USA [4]Krishna P.Singh Center for Nanotechnology,University of Pennsylvania,Philadelphia,PA 19104,USA

出　　处：《Microsystems & Nanoengineering》2015年第1期128-139,共12页微系统与纳米工程（英文）

基　　金：This work was funded by the Defense Advanced Research Projects Agency(DARPA)MTO under the auspices of Dr.Jack Judy through the Space and Naval Warfare Systems Center,Pacific Grant/Contract No.N66001-11-1-4014.

摘　　要：Extracellular matrix(ECM)-based implantable neural electrodes(NEs)were achieved using a microfabrication strategy on naturalsubstrate-based organic materials.The ECM-based design minimized the introduction of non-natural products into the brain.Further,it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions,thereby reducing inflammatory strain fields in the tissue.Preliminary studies suggested that ECM-NEs produce a reduced inflammatory response compared with inorganic rigid and flexible approaches.In vivo intracortical recordings from the rat motor cortex illustrate one mode of use for these ECM-NEs.

关 键 词：BIO-MEMS ELECTROPHYSIOLOGY extracellular matrix finite element analysis IMMUNOHISTOLOGY intracortical neural microelectrodes stress tissue-compliant electrodes 

分 类 号：TN9[电子电信—信息与通信工程]