2019年安徽省皖北、皖中和皖南地区细菌耐药差异性分析  

The analysis of antimicrobial resistance for bacteria among northern,central and southern Anhui Province in 2019

作　　者：贺玲玲 刘艳艳[1,2] 李家斌 HE Ling-ling;LIU Yan-yan;LI Jia-bin(Department of Infectious Diseases,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Anhui Center for Surveillance of Bacterial Resistance,Institute of Bacterial Resistance,Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院感染科,合肥230022 [2]安徽省细菌耐药监测中心,安徽医科大学细菌耐药研究所,合肥230022

出　　处：《中华疾病控制杂志》2021年第7期859-863,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81973983);国家科技重大专项(2017ZX10204401);2019年度合肥市“借转补”项目(J2019Y04)。

摘　　要：目的分析2019年安徽省皖北、皖中和皖南地区细菌临床分布和耐药差异性,为不同地区临床医生选择抗菌药物提供合理参考。方法收集2019年安徽省细菌耐药监测网38家成员单位临床分离菌株按地区分成皖北、皖中和皖南地区,采用WHONET 5.6软件和SPSS 17.0软件进行统计分析。结果皖北地区耐甲氧西林金黄色葡萄球菌检出率高于皖中和皖南地区,铜绿假单胞菌和鲍曼不动杆菌对头孢哌酮/舒巴坦耐药率分别为20.8%和60.4%;皖中地区耐碳青霉烯肺炎克雷伯菌高于皖北和皖南地区,肺炎克雷伯菌对头孢菌素类耐药率>40.0%,对亚胺培南和美洛培南耐药率>20.0%;皖南地区耐甲氧西林葡萄球菌对氨基糖苷类和喹诺酮类耐药率高于皖北地区。结论安徽省不同地区之间细菌耐药差异明显,需根据本地区细菌耐药情况合理选用抗菌药物。Objective To analyze the differences of clinical distribution and antimicrobial resistance of pathogenic bacteria among northern central and southern Anhui in 2019,and to provide a rational reference for clinicians in different regions.Methods The strains were collected from 38 hospitals of Anhui Center for Surveillance of Bacterial Resistance in 2019.Strains divided were according to northern,central and southern Anhui by region.WHONET 5.6 software and SPSS17.0 software were used for data analysis.Results The percentage of Methicillin-resistant Staphylococcus aureus in northern Anhui was higher than in central and southern Anhui.The resistance rates of cefoperazone/sulbactam for Pseudomonas aeruginosa and Acinetobacter baumannii were 20.8%and 60.4%,respectively.The percentage of Carbapenem-resistant Klebsiella pneumoniae in central Anhui was higher than those in northern Anhui and southern Anhui.The resistance rate of cephalothin for Klebsiella pneumoniae was>40.0%,and the resistance rates of imipenem and meropenem were>20.0%.The resistance rates of aminoglycosides and quinolones for Methicillin-resistant Staphylococcus in southern Anhui were higher than those in northern Anhui.Conclusions There are significant diffenences in bacterial resistance of different regions in Anhui Province.It is necessary to use antimicrobialagents rationally according to the resistance of bacteria in the local region.

关 键 词：细菌耐药 病原菌 抗菌药物 耐药性 

分 类 号：R378[医药卫生—病原生物学]