基于数据挖掘探讨清代名医治疗便血的用药规律  

Analysis of Medication Rule of Hematochezia Treatment by Famous Physicians in Qing Dynasty Based on Data Mining Method

作　　者：赖孔梅 林良才[1] LAI Kong-mei;LIN Liang-cai(Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China)

机构地区：[1]广州中医药大学,广东广州510405

出　　处：《中医药导报》2021年第7期173-176,195,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:基于数据挖掘探讨清代名医治疗便血的用药规律。方法:对《清代名医医案精华》所载医案进行收集、整理,采用Microsoft Office Excel 2007建立方药数据库,统计用药频数、药物分类及药物性味归经,运用IBM SPSS statistics 22.0软件对高频药物进行聚类分析,运用IBM SPSS Modeler 18.0 Apriori算法对高频药物进行关联规则分析。结果:共纳入叶天士、吴鞠通、王旭高、马培之、王九峰、张千里、巢崇山、尤在泾、曹柏仁、张聿青等10位名医治疗便血的医案39则,涉及方剂共39首,药物129种,总用药频数384,其中高频药物(出现频数≥4)37种,使用频数最多的是茯苓(15)。129种药物按功效可分为17类,其中使用频数位于前4的药物分类分别为补虚药、清热药、利水渗湿药和止血药;药性以温性、寒性、平性为主;药味以甘味药、苦味药、辛味药为主;归经以肝、脾经为主;聚类分析得到有意义的药物聚类5组;关联规则分析得到7组二阶关联和10组三阶关联。结论:清代名医治疗便血注重“血病治气”“见血不止血”,临证多选补虚之品,以甘温健脾治血。Objective: To summarize and analysis the medication rule of famous doctors in Qing Dynasty for hematochezia based on data mining. Methods: The prescriptions for treating hematochezia in Essential Medical Cases of Famous Doctors in Qing Dynasty were collected. Microsoft Excel 2007 was adopted to analyzing the frequencies, classifications, properties, flavors and meridian tropisms of herbs. IBM SPSS statistics 22.0 software was used for cluster analysis of high-frequency drugs. IBM SPSS modeler 18.0 Apriori algorithm was used to analyze the association rules of high-frequency drugs. Results: A total of 39 cases of hematochezia treated by10 famous doctors including YE Tian-shi, WU Ju-tong, WANG Xu-gao, MA Pei-zhi, WANG Jiu-feng, ZHANG Qian-li, CHAO Chong-shan, YOU Zai-jing, CAO Bai-ren, and ZHANG Yu-qing were included, involving 39 prescriptions, 129 kinds of drugs, with a total frequency of 384, including 37 kinds of high-frequency drugs(frequency≥4), and Fuling(Poria)(15) was the most frequently used. The 129 drugs were divided into 17 categories according to the efficacy. The highest frequency of the first 4 kinds of drugs were supplementing deficiency, heat clearing, diuretics for eliminating dampness and hemostatic. The medicine nature were mainly warm,cold and flat in property. The taste of medicine were mainly sweet, bitter and pungent. The channel tropism were mainly with liver and spleen meridians. Cluster analysis showed that there were 5 regular drug clusters and 7 groups of second-order association and 10 groups of third-order association are obtained by association rule analysis. Conclusion: Famous doctors in Qing Dynasty paid more attention to "treating blood and regulating Qi" and "cannot arresting blood when bleeding". Most of them chose tonic medicine to treat hematochezia by warming and invigorating the spleen.

关 键 词：便血 数据挖掘 用药规律 清代名医 

分 类 号：R266[医药卫生—中医外科学]