Implementation of soft microfingers for a hMSC aggregate manipulation system  

作　　者：Satoshi Konishi Shuhei Shimomura Shuhei Tajima Yasuhiko Tabata 

机构地区：[1]Department of Mechanical Engineering,Ritsumeikan University,1-1-1 Noji-higash,Kusatsu,Shiga 525-8577,Japan [2]Graduate School of Science and Engineering,Ritsumeikan University,1-1-1 Noji-higash,Kusatsu,Shiga 525-8577,Japan [3]Institute for Frontier Medical Sciences,Kyoto University,Yoshida-shimoadachi,Sakyo-ku,Kyoto 606-8501,Japan

出　　处：《Microsystems & Nanoengineering》2016年第1期311-317,共7页微系统与纳米工程（英文）

基　　金：This work was supported by Grant-in-Aid for Scientific Research(A):JSPS KAKENHI Grant Number 24240075.

摘　　要：This paper describes a pneumatic balloon actuator(PBA)composed of polydimethylsiloxane(PDMS)for cellular aggregate manipulation.We evaluated the ability of the microdevice to manipulate a tiny and sensitive cellular aggregate without causing serious damage.We used human mesenchymal stem cells(hMSCs)for the cellular aggregate.We describe the design,fabrication,characterization and operation of the soft microfingers to pinch and release a spherical hMSC aggregate(φ200μm),and we employed a PBA to serve as an artificial muscle to drive the microfingers.A design of the microfingers in terms of dimensions,generated force and contact conditions was accomplished.The designed dimensions of a single finger were 560μm×900μm.In summary,we demonstrate the utility of the surface modification of a fingertip for pinching and releasing a cellular aggregate and describe a manipulation system that was constructed to drive and control the microfingers.The implemented manipulation system,which is composed of microfingers and a positioning mechanism,was tested and verified in a series of operations.

关 键 词：cellular aggregate manipulation PINCHING RELEASING positioning pneumatic balloon actuator soft MEMS surface modification 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]