尿液α1-MG与血清β2-MG、TRF、Cys-C检测在早期诊断慢性肾小球肾炎中的临床价值  

Clinical Value of Urine α1-MG,Urine Transferrin,Serum β2-MG and CysC in Early Diagnosis of Chronic Glomerulonephritis

作　　者：潘枭 杨阳[2] Pan Xiao;Yang Yang(Laboratory Department,Affiliated Hospital of Chengdu University,Chengdu 610000 China;Outpatient Office,West China Hospital Of Stomatology Sichuan University,Chengdu 610000 China)

机构地区：[1]成都大学附属医院检验科,四川成都610000 [2]四川大学华西口腔医院门诊办公室,四川成都610000

出　　处：《哈尔滨医药》2021年第3期38-39,共2页Harbin Medical Journal

摘　　要：目的探讨检测尿液α1微球蛋白(α1-MG)以及血清β2微球蛋白(β2-MG)、转铁蛋白(TRF)、胱抑素(Cys)-C在早期诊断慢性肾小球肾炎中的临床应用价值。方法选择95例慢性肾小球肾炎患者,根据病理分型将其分为3组:系膜增生型为A组(35例),毛细血管型为B组(31例),膜性型为C组(29例);对照组为我院2020年6月至2020年9月的健康体检人群,共计32例。检测比较两组尿液α1-MG与血清β2-MG、TRF、Cys-C水平。结果与对照组比较,A、B、C三组的尿液α1-MG、血清TRF、血清β2-MG、血清Cys-C水平均显著升高(P<0.05);与A组比较,B组与C组上述检测指标水平升高(P<0.05);与A组与B组比较,C组上述检测指标水平升高(P<0.05)。与对照组比较,A、B、C三组的检测指标阳性率均显著升高(P<0.05);A组与B组、B组与C组的检测指标阳性率之间无统计学差异(P>0.05);与A组比较,C组检测指标阳性率升高(P<0.05)。结论慢性肾小球肾炎患者尿液α-1MG以及血清β-2MG、TRF、Cys-C水平存在异常,检测上述指标在早期诊断中具有重要的临床应用价值。Objective To investigate the clinical value of urine α 1-microglobulin(α 1-MG)and serum β 2-microglobulin(β2-MG),transferrin(TRF)and cystatin(Cys)-C in the early diagnosis of chronic glomerulonephritis.Methods 95 patients with chronic glomerulonephritis were divided into three groups according to the pathological classification:group A(35 cases)with mesangial hyperplasia,group B(31 cases)with capillary type and group C(29 cases)with membranous type;the control group was 32 healthy people in our hospital from June 2020 to September 2020.The levels of urine α1-MG and serum β2-MG,TRF and Cys-C were detected and compared between the two groups.Results Compared with the control group,the levels of urine α 1-mg,serum TRF,serum β 2-mg and serum Cys-C in group A,B and C were significantly increased(P<0.05).Compared with group A,the levels of above detection indexes in group B and group C were increased(P <0.05).Compared with group A and group B,the levels of above detection indexes in group C were increased(P<0.05).Compared with the control group,the positive rates of detection indexes were significantly increased(P<0.05).There was no statistical difference between the positive rates of detection indexes in group A with group B and group B with group C(P>0.05).There was no statistical difference between the positive rates of detection indexes in(P>0.05).Compared with group A,the positive rate of detection indexes in group C was increased(P<0.05).Conclusion The levels of α-1 mg in urine and β-2 mg,TRF and Cys-C in serum of patients with chronic glomerulonephritis are abnormal.Detection of the above indicators has important clinical value in early diagnosis.

关 键 词：慢性肾小球肾炎 Α1微球蛋白 转铁蛋白 β2微球蛋白 胱抑素C 早期诊断 

分 类 号：R692.31[医药卫生—泌尿科学]