A 3D-printed modular magnetic digital microfluidic architecture for on-demand bioanalysis  

作　　者：Pojchanun Kanitthamniyom Aiwu Zhou Shilun Feng Aiqun Liu Shawn Vasoo Yi Zhang 

机构地区：[1]Singapore Centre for 3D Printing,School of Mechanical and Aerospace Engineering,Nanyang Technological University,Singapore,Singapore [2]School of Mechanical and Aerospace Engineering,Nanyang Technological University,Singapore,Singapore [3]School of Electrical and Electronic Engineering,Nanyang Technological University,Singapore,Singapore [4]National Center for Infectious Disease,Tan Tock Seng Hospital,Singapore,Singapore

出　　处：《Microsystems & Nanoengineering》2020年第1期785-795,共11页微系统与纳米工程（英文）

基　　金：We would like to thank the funding support from Startup Grant from Nanyang Technological University,Singapore Ministry of Education Tier 1 Grant RG49/17 and RG39/19,ID POCT/17001 joint grant by HealthTech NTU/LKC Medicine/National Health Group;National Additive Manufacturing Innovation Cluster Grant 2019015;Singapore Sino-Singapore International Joint Research Institute 203-A020001.

摘　　要：Magnetic digital microfluidics(MDM)manipulates fluids in the form of droplets on an open substrate,and incorporates surface energy traps(SETs)to facilitate the droplet manipulation.Conventional MDM devices are fabricated monolithically,which makes it difficult to modify the device configuration without completely overhauling the original design.In this paper,we present a modular MDM architecture that enables rapid on-demand configuration and re-configuration of MDM platforms for customized bioanalyses.Each modular component contains a SET and a Lego-like antistud that fits onto a base board with Lego-like studs.We illustrate the versatility of the modular MDM architecture in biomarker sensing,pathogen identification,antibiotic resistance determination,and biochemical quantification by demonstrating immunoassays,phenotypical assays and enzymatic assays on various modular MDM platforms configured on demand to accomplish the fluidic operations required by assorted bioanalytical assays.The modular MDM architecture promises great potential for point-of-care diagnostics by offering on-demand customization of testing platforms for various categories of diagnostic assays.It also provides a new avenue for microfluidic assay development with its high configurability which would significantly reduce the time and cost of the development cycle.

关 键 词：CONFIGURATION operations enable 

分 类 号：TN492[电子电信—微电子学与固体电子学]