生物信息技术预警乌头类中药抗乳腺癌用药风险  

Early Warning of Aconitum Herbs in Breast Cancer Therapy by Bibliometric and Bioinformatics

作　　者：王雨[1] 林志健[1,2] 姜卓希 杨婷 王笑 张冰 WANG Yu;LIN Zhijian;JIANG Zhuoxi;YANG Ting;WANG Xiao;ZHANG Bing(School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100029,China;Center for Pharmacovigilance and Rational Use of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学中药学院,北京100029 [2]北京中医药大学中药药物警戒与合理用药研究中心,北京100029

出　　处：《中国药物警戒》2021年第7期655-662,共8页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(81673618)。

摘　　要：目的以乌头类中药抗乳腺癌研究为例,探讨毒性中药治疗恶性肿瘤的用药风险预警。方法采用文献计量学手段分析乌头类中药的不良反应/事件(ADR/AE)。采用生物信息学技术,提取基因表达数据库(gene expression omnibus,GEO)中芯片数据集GSE85871,对乌头类中药中主要生物碱成分对乳腺癌细胞MCF7差异表达基因进行基因本体论(gene oncology,GO)注释、京都基因组与基因百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路富集及蛋白质互作网络分析。结果乌头类中药治疗乳腺癌的过程中,可能会伴随醛固酮合成分泌途径、内分泌代谢途径、神经化学转导途径及骨代谢途径异常。结论在应用乌头类中药治疗乳腺癌时,须对患者循环系统、神经系统、内分泌系统、骨骼系统相关机体状态进行整体评价及密切关注,综合评估用药风险。Objective To explore the rational application of traditional Chinese medicine in cancer therapies via the treatment of breast cancer with aconitum herbs.Methods Methods of bibliometric and bioinformatics were employed.The microarray data of GSE85871 was downloaded from GEO database and analyzed by means of Gene Ontology(GO)annotation,Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis and protein-protein interaction networks.Results The treatment of breast cancer with aconitum herbs might be accompanied by abnormalities of pathways of aldosterone synthesis and secretion,endocrine metabolism,neurochemical transduction and bone metabolism.Conclusion The circulatory system,nervous system,endocrine system and skeletal system deserve attention before and during medication with aconitum herbs.

关 键 词：乌头类中药 乳腺癌 用药风险预警 文献计量学 生物信息技术 

分 类 号：R994.1[医药卫生—毒理学] R979.1[医药卫生—药学]