盐酸氨溴索联合丙酸氟替卡松治疗哮喘患儿的效果及对相关指标的影响  

Effect of Ambroxol Hydrochloride Combined with Fluticasone Propionate in the Treatment of Children with Asthma and Influence on Related Indicators

作　　者：王可 WANG Ke(Jiamusi Central Hospital,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院,黑龙江佳木斯154002

出　　处：《中国医学创新》2021年第18期14-18,共5页Medical Innovation of China

摘　　要：目的:探讨盐酸氨溴索联合丙酸氟替卡松治疗哮喘患儿的效果及相关指标的影响。方法:选取2018年5月-2020年5月146例哮喘患儿,根据随机数字表法分为对照组和观察组,每组73例。对照组给予丙酸氟替卡松治疗,观察组在对照组的基础上加用盐酸氨溴索治疗。比较两组各临床指标改善时间、治疗前和治疗后1周的PEF、PBEC计数、肺换气功能及治疗前后的白细胞介素-4、白细胞介素-5水平。结果:观察组发热、气喘、咳嗽以及肺部啰音消失时间均短于对照组,差异均有统计学意义(P<0.05)。治疗前,两组PEF、PBEC计数、RI、P_((A-a))O_(2)、Qs/Qt、Pimax比较,差异均无统计学意义(P>0.05);治疗后1周,两组PBEC计数、RI、P_((A-a))O_(2)、Qs/Qt均低于治疗前,PEF、Pimax均高于治疗前,观察组PEF、Pimax均高于对照组,PBEC计数、RI、P_((A-a))O_(2)、Qs/Qt均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组白细胞介素-4、白细胞介素-5水平比较,差异均无统计学意义(P>0.05);治疗后,观察组血清白细胞介素-4、白细胞介素-5水平均低于对照组,差异均有统计学意义(P<0.05)。结论:盐酸氨溴索联合丙酸氟替卡松治疗可改善哮喘患儿的临床症状,提高肺换气功能,减轻炎症反应且安全性较高,值得推广应用。Objective:To investigate the effect of Ambroxol Hydrochloride combined with Fluticasone Propionate in the treatment of children with asthma and the influence on related indicators.Method:A total of 146 children with asthma from May 2018 to May 2020 were selected and divided into the control group and the observation group according to random number table method,73 cases in each group.The control group was treated with Fluticasone Propionate,and the observation group was treated with Ambroxol Hydrochloride on the basis of the control group.The improvement time of clinical indexes,PEF and PBEC count,pulmonary ventilation function before treatment and 1 week after treatment,interleukin-4 and interleukin-5 levels before and after treatment were compared between two groups.Result:Fever,asthma,cough and lung rales disappeared time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in PEF,PBEC count,RI,P_((A-a))O_(2),QS/QT and Pimax between two groups(P>0.05).1 week after treatment,PBEC count,RI,P_((A-a))O_(2) and Qs/Qt of two groups were lower than those of before treatment,while PEF,Pimax were higher than those of before treatment,PEF and Pimax of the observation group were higher than those of the control group,while PBEC count,RI,P_((A-a))O_(2) and Qs/Qt were lower than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of interleukin-4 and interleukin-5 between two groups(P>0.05).After treatment,the serum levels of interleukin-4 and interleukin-5 of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:Ambroxol Hydrochloride combined with Fluticasone Propionate treatment can improve the clinical symptoms of children with asthma,improve the ventilation function of patients,reduce inflammatory response with high

关 键 词：盐酸氨溴索 丙酸氟替卡 哮喘患儿 PEF PBEC 计数 肺换气功能 

分 类 号：R725.6[医药卫生—儿科]