Glassy carbon microneedles-new transdermal drug delivery device derived from a scalable C-MEMS process  

作　　者：Richa Mishra Bidhan Pramanick Tapas Kumar Maiti Tarun Kanti Bhattacharyya 

机构地区：[1]Advanced Technology Development Center,IIT Kharagpur,Kharagpur,West Bengal 721302,India [2]Department of Mechanical Engineering,IIT Kharagpur,Kharagpur,West Bengal 721302,India [3]Biotechnology Department,IIT Kharagpur,Kharagpur,West Bengal 721302,India [4]Department of Electronics and Electrical Communication Engineering,IIT Kharagpur,Kharagpur,West Bengal 721302,India [5]School of Electrical Sciences,IIT Goa,Ponda,Goa 403401,India

出　　处：《Microsystems & Nanoengineering》2018年第1期13-23,共11页微系统与纳米工程（英文）

摘　　要：Because carbon is the basic element of all life forms and has been successfully applied as a material for medical applications,it is desirable to investigate carbon for drug delivery applications,as well.In this work,we report the fabrication of a hollow carbon microneedle array with flow channels using a conventional carbonmicroelectromechanical system(C-MEMS)process.This process utilizes the scalable and irreversible step of pyrolysis,where prepatterned SU-8 microneedles(precursor)are converted to glassy carbon structures in an inert atmosphere at high temperature(900°C)while retaining their original shape upon shrinkage.Once converted to glassy carbon,the microneedles inherit the unique properties of hardness,biocompatibility,and thermal and chemical resistance associated with this material.A comparative study of hardness and Young’s modulus for carbon microneedles and SU-8 microneedles was performed to evaluate the increased strength of the microneedles induced by the C-MEMS process steps.Structural shrinkage of the carbon microneedles upon pyrolysis was observed and estimated.Material characterizations including energy-dispersive X-ray spectroscopy(EDX)and Raman spectroscopy were carried out to estimate the atomic percentage of carbon in the microneedle structure and its crystalline nature,respectively.Our investigations confirm that the microneedles are glassy in nature.Compression and bending tests were also performed to determine the maximum forces that the carbon microneedles can withstand,and it was found that these forces were approximately two orders of magnitude higher than the resistive forces presented by skin.A microneedle array was inserted into mouse skin multiple times and was successfully removed without the breakage of any microneedles.

关 键 词：carbon process NEEDLE 

分 类 号：TG1[金属学及工艺—金属学]