Etiopathogenesis of reproductive tract infections and the emerging role of bitter taste receptors:A scoping review  

作　　者：Menizibeya O.Welcome Abraham Jeremiah Dennis O.Allagoa Senol Dane Vladimir A.Pereverzev 

机构地区：[1]Department of Physiology,Faculty of Basic Medical Sciences,Nile University of Nigeria,Abuja,Nigeria [2]Department of Surgery,Federal Medical Centre,Yenagoa,Nigeria [3]Department of Surgery,Belarusian State Medical University,Minsk,Belarus [4]Department of Obstetrics and Gynecology,Federal Medical Centre,Yenagoa,Nigeria [5]Department of Normal Physiology,Belarusian State Medical University,Minsk,Belarus

出　　处：《Asian pacific Journal of Reproduction》2021年第4期145-154,共10页亚太生殖杂志（英文版）

摘　　要：Reproductive tract infections pose an immense public health concern worldwide as over 600 million new cases are recorded annually along with several complications,including infertility,ectopic pregnancy,preterm delivery,and neonatal death.Despite improved understanding of the mechanisms of pathogenic invasion,the etiopathogenesis of reproductive tract infections is yet to be completely understood.Recent data has suggested a critical role of bitter taste receptors of the reproductive tract in etiopathogenesis of reproductive tract infections.Here,we review the literature on current etiopathogenesis of reproductive tract infections and the role of bitter taste receptors of the reproductive tract in etiopathogenesis of reproductive tract infections.Emerging evidence suggests a critical role of microbiota disorder of the reproductive tract in reproductive tract infections.Several bacterial,protozoan parasitic,helminthic parasitic and viral pathogens have been identified as causative agents of reproductive tract infections.These pathogens subvert host defenses and activate specific architectural units of the uroepithelium such as Toll-like receptors,which recognize conserved motifs on the pathogens.The activated Toll-like receptors mediate downstream signaling,stimulating nuclear factor-κB,which in turn activates the production of proinflammatory cytokines.This pathway is also associated with recruitment of immunocytes to the site of aggression and release of proteinases,which drive tissue damage in the reproductive tract.Defects in detection of pathogenic components by the bitter taste receptors of the reproductive tract may play a critical role in the etiopathogenesis of reproductive tract infections.This review provides important information for identification of novel frontiers for the treatment of reproductive tract infections.

关 键 词：INFECTION Genital inflammation REPRODUCTION Reproductive tract infections Bitter taste receptor ETIOPATHOGENESIS CYTOKINES 

分 类 号：R16[医药卫生—公共卫生与预防医学]