血清黏附分子及血管内皮损伤因子与妊娠期高血压疾病严重程度的关系分析  

Analysis on the Relationship between Serum Adhesion Molecules,Vascular Endothelial Injury Factors and Severity of Hypertensive Disorder Complicating Pregnancy

作　　者：秦慧燕 常闪闪 QIN Huiyan;CHANG Shanshan(The First People’s Hospital of Shangqiu City,Shangqiu 476000,China;不详)

机构地区：[1]河南省商丘市第一人民医院,河南商丘476000

出　　处：《中国医学创新》2021年第19期114-117,共4页Medical Innovation of China

摘　　要：目的:探究与观察血清黏附分子及血管内皮损伤因子与妊娠期高血压疾病严重程度的关系。方法:选取2019年8月-2020年8月的124例妊娠期高血压疾病患者为观察组,同时期的124例健康孕妇为对照组。检测与比较两组的血清黏附分子(sICAM-1、sVCAM-1、PECAM-1)及血管内皮损伤因子(hs-CRP、ET-1、ACA-IgM、ACA-IgG),比较观察组中不同严重程度者的血清黏附分子及血管内皮损伤因子,采用Spearman秩相关分析上述血清指标与妊娠期高血压疾病严重程度的关系。结果:观察组的血清PECAM-1显著低于对照组,其他血清黏附分子及血管内皮损伤因子均显著高于对照组,观察组中不同严重程度者的血清黏附分子及血管内皮损伤因子比较,差异均有统计学意义(P<0.05);Spearman秩相关分析显示,血清PECAM-1与妊娠期高血压疾病严重程度呈负相关,其他血清黏附分子及血管内皮损伤因子与妊娠期高血压疾病严重程度呈正相关(P<0.05)。结论:妊娠期高血压疾病患者的血清黏附分子及血管内皮损伤因子表达显著异常,且与疾病严重程度密切相关,因此在妊娠期高血压疾病患者中的检测价值较高。Objective:To investigate and observe the relationship between serum adhesion molecules,vascular endothelial injury factors and severity of hypertensive disorder complicating pregnancy.Method:A total of 124 patients with hypertensive disorder complicating pregnancy from August 2019 to August 2020 were chosen as the observation group,124 healthy pregnant women at the same time were chosen as the control group.Then the serum adhesion molecules(sICAM-1,sVCAM-1 and PECAM-1)and vascular endothelial injury factors(hs-CRP,ET-1,ACA-IgM and ACA-IgG)of two groups were compared,and the serum adhesion molecules and vascular endothelial injury factors of observation group with different severity were compared too,then the relationship between those serum indexes and severity of hypertensive disorder complicating pregnancy were analyzed with Spearman rank correlation analysis.Result:The serum PECAM-1 of observation group was significantly lower than that of control group,other serum adhesion molecules and vascular endothelial injury factors were significantly higher than those of control group,the serum adhesion molecules and vascular endothelial injury factors of observation group with different severity were compared,there were statistically significant differences(P<0.05).The Spearman rank correlation analysis showed the serum PECAM-1 was negatively correlated with severity of hypertensive disorder complicating pregnancy,other serum adhesion molecules and vascular endothelial injury factors were positively correlated with severity of hypertensive disorder complicating pregnancy(P<0.05).Conclusion:The serum adhesion molecules and vascular endothelial injury factors and severity of hypertensive disorder complicating pregnancy are significantly abnormal,and they have close relationship with the severity of disease,so the detection value in the patients with hypertensive disorder complicating pregnancy are higher.

关 键 词：妊娠期高血压疾病 黏附分子 血管内皮损伤因子 

分 类 号：R714.246[医药卫生—妇产科学]