5-甲酰基尿嘧啶合成工艺研究  

Study on Synthesis Technology of 5-formyluracil

作　　者：詹庆明 席锐 叶俊文 龙艳 杨维清 Zhan Qingming;Xi Rui;Ye Junwen;Long Yan;Yang Weiqing(Faculty of Science,Xihua University,Sichuan Chengdu 610041)

机构地区：[1]西华大学理学院,四川成都610041

出　　处：《化工时刊》2021年第7期1-3,共3页Chemical Industry Times

基　　金：四川省创新训练项目(201610623058);教育部春晖计划(Z2016163)。

摘　　要：本文研究了5-甲酰基尿嘧啶的合成新工艺。该工艺原料易得,反应条件温和,收率高。首先以尿嘧啶为底物,与多聚甲醛进行羟甲基化反应,制备得到5-羟甲基尿嘧啶中间体,进一步以该中间体为底物进行氧化反应,制备得到5-甲酰基尿嘧啶。重点考察了反应时间、溶剂、温度、催化剂等四类条件对氧化反应的影响。最终以尿嘧啶为起始原料制备5-甲酰基尿嘧啶,两步反应总收率可以达到75%以上,并对目标产物采用氢核磁共振进行了结构表征。In this paper,a new process for the synthesis of 5-formyluracil was studied.The raw materials were readily available,and the reaction conditions were mild withhigh yield.First,for preparingthe 5-hydroxymethyluracil intermediate,uracil was used as a substrate to undergo a methylation-reaction with paraformaldehyde.And then,the 5-hydroxymethyluracilwas used as a substrate to prepare 5-formyluracil through oxidation reaction.The effects of reaction time,solvent,temperature and catalyst on oxidation reaction were investigated.Finally,the optimal reaction conditions for the preparation of 5-formyluracil were obtained.5-Formyl uracil was prepared from uracil,and the total yield of two-step reaction was more than 75%.The target product was characterized by nuclear magnetic resonance.

关 键 词：尿嘧啶 5-甲酰基尿嘧啶 氧化反应 硝酸铈铵 合成 

分 类 号：O626[理学—有机化学]