抗着丝点抗体阳性患者临床诊断研究  

Clinical Diagnosis of Patients with Positive Anti-Centromere Antibody

作　　者：张若冰 陈福军 郝武常 武易 ZHANG Ruobing;CHEN Fujun;HAO Wuchang;WU Yi(Shaanxi Center for New Drug Evaluation,Xi'an,Shaanxi,China 710065;Institute for Certification and Evaluation,Liaoning Inspection,Examination and Certification Centre,Shenyang,Liaoning,China 110003;Department of Laboratory,No.986 Hospital of the Air Force of the PLA,Xi'an,Shaanxi,China 710054)

机构地区：[1]陕西省新药审评中心,陕西西安710065 [2]辽宁省检验检测认证中心认证审评院,辽宁沈阳110003 [3]中国人民解放军空军第986医院检验科,陕西西安710054

出　　处：《中国药业》2021年第15期99-101,共3页China Pharmaceuticals

摘　　要：目的探讨抗着丝点抗体(ACA)在不同疾病类型中抗体阳性的患者分布,以及在临床诊断疾病中的应用价值。方法回顾性分析中国人民解放军第986医院2012年3月至2018年3月收治的抗核抗体(ANA)146例ACA阳性患者的临床和相关实验室检查资料。结果自身免疫性疾病患者83例(56.85%),其中自身免疫性乙型肝炎患者34例(40.96%),混合肝病和结缔组织性疾病患者15例(18.07%),重叠综合征患者13例(15.66%),系统性红斑狼疮患者8例(9.64%),类风湿关节炎患者7例(8.43%);非自身免疫性疾病患者63例(43.13%),其中血液内分泌系统疾病患者16例(25.40%),心血管系统疾病患者14例(22.22%),泌尿系统疾病患者11例(17.46%),呼吸系统疾病患者7例(11.11%),消化统疾病患者4例(6.35%);146例ACA阳性患者中,贫血症患者80例(54.79%),肝功能异常(主要是丙氨酸氨基转移酶和天门冬氨酸氨基转移酶异常)患者62例(42.47%),红细胞沉降率异常患者44例(30.14%)。结论 ACA对自身免疫性疾病的诊断具有一定特异性,与自身免疫性肝病联系紧密。Objective To investigate the distribution of anti-centromere antibody(ACA)positive in different types of diseases and its application value in clinical diagnosis.Methods The clinical examination information and relevant laboratory examination data of 146 anti-nuclear antibody(ANA)positive and ACA-positive patients admitted to the No.986 Hospital of the PLA from March 2012 to March 2018 were analyzed retrospectively.Results A total of 83 ACA-positive patients(56.85%)had autoimmune diseases,including 34 patients(40.96%)with autoimmune hepatitis B,15 patients(18.07%)with mixed liver disease and connective tissue disease,13 patients(15.66%)with overlap syndrome,8 patients(9.64%)with systemic lupus erythematosus(SLE)and 7 patients(8.43%)with rheumatoid arthritis(RA).A total of 63 ACA-postive patients(43.13%)had non-autoimmune diseases,including 16 patients(25.40%)with blood endocrine system diseases,14 patients(22.22%)with cardiovascular system diseases,11 patients(17.46%)with urinary system diseases,7 patients(11.11%)with respiratory system diseases,and 4 patients(6.35%)with digestive system diseases.In the 146 patients with positive ACA,there were 80 patients(54.79%)with anemia,62 patients(42.47%)with abnormal liver function(mainly alanine transferase and aspartate transferase),and 44 patients(30.14%)with abnormal erythrocyte sedimentation rate.Conclusion ACA has a certain specificity in the diagnosis of autoimmune diseases and it is closely related to autoimmune liver diseases.

关 键 词：抗着丝点抗体 自身免疫性疾病 非自身免疫性疾病 回顾性分析 临床诊断 

分 类 号：R446[医药卫生—诊断学]