调经促孕十三针在辅助生殖技术中改善卵巢储备功能的临床研究  

Clinical study on improving ovarian reserve function by regulating menstruation and promoting pregnancy by thirteen acupuncture in assisted reproductive technology

作　　者：张君探[1] 刘淑兰[2] 高晓宁 王崇兰[1] 陈昭萌 张兴兴 徐艳 赵淑芹[1] ZHANG Juntan;LIU Shulan;GAO Xiaoning;WANG Chonglan;CHEN Zhaomeng;ZHANG Xingxing;XU Yan;ZHAO Shuqin(Department of Reproduc¬tive Medicine,Zaozhuang Maternal and Child Health Hospital,Zaozhuang 277100,Shandong,China;Department of Obstetrics and Gynecology,Zaozhuang Maternal and Child Health Hospital,Zaozhuang 277100,Shandong,China)

机构地区：[1]枣庄市妇幼保健院生殖医学科,山东枣庄277100 [2]枣庄市妇幼保健院妇产科,山东枣庄277100

出　　处：《中国性科学》2021年第7期96-99,共4页Chinese Journal of Human Sexuality

基　　金：山东省中医药科技发展计划项目(2019-0656)。

摘　　要：目的结合辅助生殖技术,从卵子、胚胎的角度探讨调经促孕十三针治疗卵巢储备功能减退(DOR)的有效性。方法选取2018年10月至2020年7月枣庄市妇幼保健院收治的60例行第3周期IVF-ET合并既往取卵2周期无可用胚的DOR患者作为研究对象。根据是否采用针灸治疗分为实验组与对照组,比较两组治疗前后相关指标。结果治疗后,实验组基础卵泡刺激素水平较对照组低,可用胚数、妊娠率均较对照组高,差异具有统计学意义(P<0.05);实验组窦卵泡数、获卵数、减数分裂Ⅱ期(MⅡ)卵数、获胚率均较对照组高,但差异无统计学意义(P>0.05)。结论调经促孕十三针可改善DOR患者卵子数量、质量及可用胚数,联合辅助生殖技术可有效提高妊娠率,为DOR尤其是难获胚性DOR导致的不孕症的治疗提供新的联合治疗思路。Objective To explore the efficacy of regulating menstruation and promoting pregnancy 13 acupuncture in the treatment of decreased ovarian reserve(DOR) function with assisted reproductive technology from the perspective of egg and embryo. Methods 60 patients with DOR who underwent cycle 3 in vitro fertilization and embryo transfer(IVF-ET) combined with no usable embryos from cycle 2 of previous egg collection were selected as the research subjects from October 2018 to July 2020 in Zaozhuang Maternal and Child Health Hospital. According to whether acupuncture treatment was used, the two groups were divided into experimental group and control group, and the relevant indexes before and after treatment were compared. Results After treatment, the basal follicle stimulating hormone level in the experimental group was lower than that in the control group, while the number of embryos available and pregnancy rate were higher than those in the control group(P<0.05). The number of antral follicles, the number of eggs obtained, the number of eggs at Metaphase Ⅱ and embryo obtained rate in the experimental group were higher than those in the control group, but the differences were not statistically significant(P>0.05).Conclusions The regulating menstruation and promoting pregnancy by thirteen acupuncture can improve the egg quantity, quality and number of available embryos in patients with DOR, and combined assisted reproductive technology can effectively improve the pregnancy rate, which provides a new combination treatment idea for the treatment of DOR, especially the refractory embryonic DOR infertility, and is worthy of promotion and application.

关 键 词：卵巢储备功能减退 调经促孕十三针 针刺 体外受精-胚胎移植术 

分 类 号：R275[医药卫生—中医皮科] R711[医药卫生—中医学]