基于杂原子掺杂介孔碳球纳米酶的抗肿瘤药物构建  

Construction of Antitumor Drugs Based on Heteroatom-doped Mesoporous Carbon Ball Nanoenzyme

作　　者：顾文贤 Gu Wenxian(College of Chemistry&Materials Engineering,Wenzhou University,Zhejiang,325035)

机构地区：[1]温州大学化学与材料工程学院,浙江325035

出　　处：《当代化工研究》2021年第15期35-36,共2页Modern Chemical Research

摘　　要：酶介导的纳米抗肿瘤药物治疗是一种有效的靶向治疗肿瘤细胞的策略。杂原子掺杂的介孔碳纳米球,依据肿瘤微环境特异性响应的特点,已经取得了一定的进展。本文围绕修饰有铁蛋白的氮掺杂介孔碳球、修饰叶酸负载有吲哚乙酸的氮磷共掺杂介孔中心碳球以及氮掺杂介孔中空碳纳米球与铁酞菁结合进行综述,阐述了杂原子掺杂的碳基材料作为纳米酶应用于抗肿瘤药物体系的策略和机制。Enzyme-mediated nano anti-tumor drug therapy is an effective strategy for targeted treatment of tumor cells.Heteroatom-doped mesoporous carbon nanospheres have made some progress according to the specific response characteristics of tumor microenvironment.In this paper,the nitrogen-doped mesoporous carbon spheres modified with ferritin,the nitrogen-phosphorus co-doped mesoporous central carbon spheres modified with folic acid and loaded with indoleacetic acid,and the combination of nitrogen-doped mesoporous hollow carbon nanospheres and iron phthalocyanine were reviewed,and the strategies and mechanisms of heteroatom-doped carbon-based materials as nanoenzymes applied to anti-tumor drug systems were expounded.

关 键 词：氮掺杂 氮磷共掺杂 抗肿瘤药物 碳基纳米材料 靶向治疗 

分 类 号：TQ[化学工程]