阿昔洛韦联合匹多莫德口服液在小儿传染性单核细胞增多症治疗中的效果  

Effect of Acyclovir Combined with Pidotimod Oral Liquid in the Treatment of Infectious Mononucleosis in Children

作　　者：陈清凤 余本立 方艳莹 陈丽容 CHEN Qingfeng;YU Benli;FANG Yanying;CHEN Lirong(Kaiping Central Hospital,Kaiping 529300,China;不详)

机构地区：[1]开平市中心医院,广东开平529300

出　　处：《中外医学研究》2021年第19期51-53,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨阿昔洛韦联合匹多莫德口服液在小儿传染性单核细胞增多症(IM)治疗中的效果。方法:选择2018年10月-2019年10月本院治疗的IM患儿88例。按照随机数字表法分为观察组(n=44)及对照组(n=44)。对照组给予阿昔洛韦治疗,观察组在对照组基础上给予匹多莫德口服液治疗。比较两组疗效、症状及体征(退热、肝脾缩小、淋巴结缩小)缓解时间、住院天数,比较两组治疗前后T淋巴细胞亚群水平(CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+))。结果:治疗后,观察组总有效率较对照组高(P<0.05), 观察组肝脾缩小、退热、淋巴结缩小时间及住院时间均优于对照组,差异有统计学意义(P<0.05), 治疗后,观察组CD8^(+)水平低于对照组,CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)高于对照组,差异有统计学意义(P<0.05)。结论:阿昔洛韦联合匹多莫德口服液治疗小儿IM效果显著,可促进患儿症状及体征缓解,改善免疫功能。Objective:To explore the effect of Acyclovir combined with Pidotimod Oral Liquid in the treatment of infectious mononucleosis(IM)in children,so as to provide the basis for the clinical application of the scheme.Method:A total of 88 children with IM treated in our hospital from October 2018 to October 2019 were selected and divided into the observation group(n=44)and the control group(n=44)according to random number table method.The control group was treated with Acyclovir,and the observation group was treated with Pidotimod Oral Liquid on the basis of the control group.The curative effect,remission time of symptoms and signs(fever abatement,liver and spleen shrinking,lymph node shrinking)and hospitalization time were compared between the two groups.The levels of T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+) and CD4^(+)/CD8^(+))before and after treatment were compared between the two groups.Result:After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05);the time of liver and spleen shrinking,fever abatement,lymph node shrinking and hospitalization time of the observation group were better than those of the control group,and the differences were statistically significant(P<0.05);after treatment,the level of CD8^(+) in the two groups was lower than that before treatment,and the levels of CD3^(+),CD4^(+) and CD4^(+)/CD8^(+) in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Acyclovir combined with Pidotimod Oral Liquid is effective in the treatment of IM in children,which can promote the remission of symptoms and signs,and improve the immune function.

关 键 词：传染性单核细胞增多症 阿昔洛韦 匹多莫德口服液 

分 类 号：R725.1[医药卫生—儿科]