GCB与非GCB来源的甲状腺DLBCL的临床及超声特征研究  

Clinical and Ultrasonic Characteristics of Thyroid DLBCL of GCB and Non-GCB Origin

作　　者：商雷 岳灿 赵海娜[1] 赵莎[2] 马步云[1] Shang Lei;Yue Can;Zhao Haina;Zhao Sha;Ma Buyun(Department of Ultrasound,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China;Department of Pathology,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西医院超声医学科,成都市610041 [2]四川大学华西医院病理科,成都市610041

出　　处：《中国超声医学杂志》2021年第8期852-854,共3页Chinese Journal of Ultrasound in Medicine

基　　金：四川省科技厅(No.2018RZ0138)。

摘　　要：目的探讨甲状腺弥漫大B细胞淋巴瘤(DLBCL)生发中心B细胞来源(GCB)与非生发中心B细胞来源(NGCB)的临床及超声特征。方法将病理证实为甲状腺DLBCL的49例患者以Hans分类标准分为GCB组和NGCB组,分析两组患者的临床及超声特征。结果 GCB组的OTA超声分型多为结节型,NGCB组多为弥漫型,差异有统计学意义(P<0.05);肿瘤病灶边界不清、颈部有肿大淋巴结,NGCB组多于GCB组,差异有统计学意义(P<0.05);两组患者性别、年龄,肿瘤的最大径、数目、位置、形态、有无甲状腺被膜侵犯、Adler血流分级,差异无统计学意义(P>0.05)。结论 NGCB与GCB的超声征象存在一定差异,病灶边界不清、有颈部淋巴结肿大和OTA超声分型为弥漫型时应考虑NGCB来源的DLBCL可能。Objective To investigate the clinical and ultrasonic characteristics of DLBCL in germinal center B-cell source(GCB) and non-germinal center B-cell source(NGCB). Methods 49 patients with thyroid DLBCL confirmed by preoperative biopsy or surgical pathology were divided into GCB group and NGCB group according to Hans classification criteria, and the clinical and ultrasonic characteristics of the two groups were analyzed. Results The OTA classification of the GCB group was mostly nodular, while that of the NGCB group was diffuse, and the difference was statistically significant(P<0.05). NGCB group was more than GCB group, with statistically significant difference(P<0.05). Two groups of patients with gender, age, tumor of the largest diameter, number, location, shape, with and without infringement of thyroid capsule, Adler blood flow grade, there was no statistically significant difference(P>0.05). Conclusions There are some differences between the ultrasonic signs of NGCB and GCB, and the possibility of DLBCL from NGCB phenotype should be considered when the lesion boundary is unclear, cervical lymph node enlargement is present, and OTA ultrasound classification is diffuse type.

关 键 词：甲状腺 弥漫大B细胞淋巴瘤 生发中心 非生发中心 超声检查 

分 类 号：R445.1[医药卫生—影像医学与核医学] R736.1[医药卫生—诊断学]