急性心肌梗死患者血清基质细胞衍生因子-1、CXC趋化因子受体4表达水平与血小板活化的关系及对预后的影响研究  

The relationship between serum SDF-1,CXCR4 expressions and platelet activation in patients with acute myocardial infarction and its influence on prognosis

作　　者：杨建广[1] 任诗佳 汪凌清 刘文华[1] 郑继平[1] YANG Jian-guang;REN Shi-jia;WANG Ling-qing;LIU Wen-hua;ZHENG Ji-ping(Department of Cardiovascular Medicine,First People's Hospital of Taizhou,Taizhou,Zhejiang 318020,China)

机构地区：[1]台州市第一人民医院心血管内科,浙江台州318020

出　　处：《中国卫生检验杂志》2021年第13期1580-1583,共4页Chinese Journal of Health Laboratory Technology

基　　金：浙江省医药卫生科技计划项目(2017KY171)。

摘　　要：目的探讨急性心肌梗死患者血清基质细胞衍生因子-1(SDF-1)、CXC趋化因子受体4(CXCR4)表达水平与血小板活化的关系及对预后的影响。方法选取2017年3月—2018年10月台州市第一人民医院收治的94例急性心水平,流式细胞术检测血小板活化标志物P-选择素(CD62p)、CD40配体(CD40L)、血小板激活复合物-1(PAC-1)表达,采用Person相关性分析探究SDF-1、CXCR4与血小板活化标志物的相关性,所有患者随访1年,依据主要心脏不良事件发生情况分为预后不良组及预后良好组,分析影响患者预后的危险因素。结果研究组患者血清SDF-1、CXCR4水平高于对照组(P<0.05);研究组患者全血CD62p、CD40L、PAC-1表达水平高于对照组(P<0.05);血清SDF-1、CXCR4与CD62p、CD40L、PAC-1表达呈正相关(P<0.05);预后不良组血清SDF-1、CXCR4水平显著高于预后良好组(P<0.05);多因素Logistic分析结果显示,SDF-1、CXCR4是影响患者预后危险因素(P<0.05)。结论急性心肌梗死患者血清SDF-1、CXCR4水平升高,血小板活化能力增强,可作为预后评估有效预测因子。Objective To investigate the relationship between the expressions of serum stromal cell derived factor-1(SDF-1),CXC chemokine receptor 4(CXCR4)and platelet activation in patients with acute myocardial infarction and its influence on prognosis.Methods Ninety-four patients with acute myocardial infarction admitted to First People's Hospital of Taizhou from March 2017 to October 2018 were selected as the study subjects,and ninety healthy people in the same period were selected as the control group.The serum SDF-1 and CXCR4 were detected by enzyme-linked immunosorbent assay,the expressions of platelet activation markers P-selectin(CD62p),CD40 ligand(CD40L)and platelet activation complex-1(PAC-1)were detected by flow cytometry,the correlation between SDF-1,CXCR4 and platelet activation markers was studied by person correlation analysis,all patients were followed up for one year;they were divided into poor prognosis group and good prognosis group according to the occurrence of major adverse cardiac events,and the risk factors affecting the prognosis were analyzed.Results The levels of serum SDF-1 and CXCR4 in the study group were higher than those in the control group(P<0.05);the expression levels of CD62p,CD40L and PAC-1 in the whole blood of the study group were higher than those of the control group(P<0.05);serum SDF-1 and CXCR4 were positively correlated with CD62p,CD40L and PAC-1(P<0.05);the levels of serum SDF-1 and CXCR4 in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05);the results of multivariate logistic analysis showed that SDF-1 and CXCR4 were the risk factors of prognosis(P<0.05).Conclusion Serum SDF-1 and CXCR4 levels in patients with acute myocardial infarction are elevated and platelet activation ability is enhanced,which can be used as an effective predictor of prognosis.

关 键 词：急性心肌梗死 基质细胞衍生因子-1 CXC趋化因子受体4 血小板活化 预后 

分 类 号：R542.22[医药卫生—心血管疾病]