外泌体在放射医学中的应用与机制研究进展  

Research progress in the application of exosomes in radiological medicine and underlying mechanisms

作　　者：殷娅茹 杨露勋 刘晶 卢丙慧 李蓉 Yin Yaru;Yang Luxun;Liu Jing;Lu Binghui;Li Rong(Institute of Combined Injury,State Key Laboratory of Trauma,Burns and Combined Injury,Military Key Laboratory of Nanomedicine,Department of Military Preventive Medicine,Army Medical University,Chongqing 400038,China)

机构地区：[1]陆军军医大学军事预防医学系复合伤研究所,创伤烧伤复合伤国家重点实验室,全军纳米医学重点实验室,重庆400038

出　　处：《中华放射医学与防护杂志》2021年第7期547-551,共5页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金(81773364);四川省自然基金重点项目(2017SZ0004);全军后勤科研重大项目(AWS17J007)。

摘　　要：核能在军事、医疗、科研和工农业等各个领域应用广泛,在发生事故时可能存在对机体的辐射损伤。目前对重度以上骨髓型放射病的治疗效果依然不理想。外泌体是由活细胞分泌的、大小为30~130 nm的小囊泡,可携带包括蛋白质、RNA、DNA等多种活性物质,是细胞间通讯的重要媒介。外泌体中的内含物不仅可用于辐射损伤的生物标记物,还可用于辐射损伤的治疗。本文对外泌体在放射医学中的应用和机制等研究进展进行了综述。Nuclear energy is widely used in various fields such as military,medicine,scientific research,industry and agriculture.Nuclear accident may lead to radiation damage to the bodyofpractitioners.At present,the treatment of severe bone marrow radiation sickness is still not ideal.Exosomes are small vesicles with a size of 30-130 nm secreted by living cells and carry a variety of active substances including protein,RNA,DNA,which isimportant medium of intercellular communication.The contents of exosomes can be used not only as biomarkers of radiation damage,but also for the treatment of radiation damage.This article reviewsthe research progress of the application of exosomes in radiological medicine and underlying mechanisms.

关 键 词：外泌体 辐射 旁效应 放射性损伤 肿瘤 

分 类 号：R817[医药卫生—影像医学与核医学]