甘草酸对姜黄素凝胶体外透皮性能的影响  

Influence of glycyrrhizin on transdermal absorption properties in vitro of curcumin gel

作　　者：朱溶月 杨魏静 常道潇 王文苹[1,3] ZHU Rong-yue;YANG Wei-jing;CHANG Dao-xiao;WANG Wen-ping(School of Pharmacy,Ningxia Medical University,Yinchuan 750004,China;Key Laboratory of Hui Medicine Ministry of Education,Yinchuan 750004,China;School of Chinese Mateira Medica,Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]宁夏医科大学药学院,银川750004 [2]回医药现代化教育部重点实验室,银川750004 [3]云南中医药大学中药学院,昆明650500

出　　处：《中华中医药杂志》2021年第6期3607-3609,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：宁夏自然科学基金重点项目(No.NZ17060)。

摘　　要：目的:考察甘草酸对姜黄素透皮吸收行为的影响。方法:采用Franz扩散池,以离体大鼠皮肤为渗透屏障,考察不同浓度甘草酸对姜黄素凝胶中药物的单位面积累积渗透量,稳态渗透速率及渗透系数、皮肤滞留量等参数的影响。结果:高浓度甘草酸组可显著促进姜黄素透皮吸收,效果与5%Cremophor EL相近,中、低浓度甘草酸组则无促渗作用,但各浓度甘草酸均可显著提高姜黄素在皮肤内的滞留量。结论:甘草酸可提高难溶性药物姜黄素在皮肤内含量,且在一定浓度时能改善透皮吸收性能。Objective:To study the influence of glycyrrhizin on transdermal property of curcumin.Methods:The transdermal parameters of curcumin gel with different concentration of glycyrrhizin were tested ex vivo and compared by Franz diffusion cell method on rat skin.Results:High concentration glycyrrhizin could enhance the permeation of curcumin just like 5%Cremophor EL did,but glycyrrhizin at lower and medium concentrations couldn’t enhance the permeation.The drug retention in rat skin was improved with the addition of all concentration glycyrrhizin.Conclusion:Glycyrrhizin showed a favorable effect on drug retention in rat skin and could enhance the permeation performance of curcumin at a certain content.

关 键 词：甘草酸 姜黄素 透皮给药 经皮吸收促渗剂 皮肤滞留量 

分 类 号：R285[医药卫生—中药学]