清肺培元颗粒对艾滋病合并肺部感染痰热壅肺证患者Th1/Th2的影响  

Effects of Qingfei Peiyuan Granules on Th1/Th2 in patients with AIDS complicated with pulmonary infection with phlegm-heat obstructing lung syndrome

作　　者：马秀霞[1,2,3] 桑锋 崔伟锋[4] 孟鹏飞 丁雪[2,3] 扶伟[5] 王豪杰 韩迎东[6] 宋夕元 李亮平[2,3] 徐立然 MA Xiu-xia;SANG Feng;CUI Wei-feng;MENG Peng-fei;DING Xue;FU Wei;WANG Hao-jie;HAN Ying-dong;SONG Xi-yuan;LI Liang-ping;XU Li-ran(Henan University of Chinese Medicine,Zhengzhou 450006,China;The First Affiliated Hospital of Henan University of CM,Zhengzhou 450000,China;Henan Key Laboratory of TCM for the Prevention and Treatment of Viral Diseases,Zhengzhou 450000,China;The Affiliated Hospital of Henan Institute of Traditional Chinese Medicine,Zhengzhou 450004,China;Henan Provincial Chest Hosptial,Zhengzhou 450008,China;Zhengzhou City Center Hospital,Zhengzhou 450007,China)

机构地区：[1]河南中医药大学,郑州450006 [2]河南中医药大学第一附属医院,郑州450000 [3]河南省病毒性疾病中医药防治重点实验室,郑州450000 [4]河南省中医药研究院附属医院,郑州450004 [5]河南省胸科医院,郑州450008 [6]郑州市中心医院,郑州450007

出　　处：《中华中医药杂志》2021年第6期3721-3724,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家十三五科技重大专项(No.2017ZX10205502);河南省科技攻关项目(No.182102310264);河南省科技创新杰出人才项目(No.154200510016);河南省中医管理局国家中医临床研究基地专项(No.2017JDZX001);河南省中医药科学研究专项(No.2015ZY02097,No.2016ZY2036,No.2019AZB009,No.2019AZB011)。

摘　　要：目的:探讨清肺培元颗粒对艾滋病肺部感染痰热壅肺证患者的作用机制。方法:选择艾滋病肺部感染痰热壅肺证患者72例,随机分为36例治疗组,36例对照组,在西医基础治疗的基础上治疗组服用清肺培元颗粒药物,对照组服用清肺培元颗粒模拟剂,治疗观察14d,检测患者的免疫功能,Th1、Th2相关细胞因子。结果:治疗后,与对照组比较,清肺培元颗粒有提高患者免疫功能的趋势,Th1相关细胞因子IL-2、Th2相关细胞因子IL-6表达显著提高(P<0.05),Th2相关细胞因子IL-12、IFN-γ、TNF-α、IL-4、IL-10表达显著降低(P<0.05)。结论:清肺培元颗粒治疗艾滋病肺部感染痰热壅肺患者的机制之一可能是调节Th1/Th2的免疫失衡。Objective:To investigate the mechanism of Qingfei Peiyuan Granules on patients with phlegm-heat obstructing lung syndrome of AIDS pulmonary infection.Methods:A total of 72 patients with AIDS pulmonary infection with phlegm-heat obstructing lung syndrome were randomly divided into 36 experimental groups and 36 control groups,based on western medicine therapy on the basis of the experimental group Qingfei Peiyuan Granules,control group take Qingfei Peiyuan Granules simulation agent,treatment of observation for 14 days,test the patient’s immune function,Th1,Th2 cytokines.Results:After the treatment,compared with the control group,Qingfei Peiyuan Granules had a tendency to improve the immune function of patients,increased the expression of Th1 cytokines such as IL-2 and Th2 cytokines such as IL-6(P<0.05),reduced the expression of Th2 cytokines such as IL-12,IFN-γ,TNF-α,IL-4,IL-10(P<0.05).Conclusion:Qingfei Peiyuan Granules may improve immune function by regulating Th1/Th2 imbalance in the treatment of AIDS pulmonary infection with phlegm-heat obstructing lung patients.

关 键 词：艾滋病 肺部感染 痰热壅肺 清肺培元 TH1/TH2 

分 类 号：R259[医药卫生—中西医结合]