清利活血解毒汤联合肿痛消外敷对老年急性痛风性关节炎关节功能的影响  

Effect of Qingli Huoxue Jiedu Decoction Combined with Zhongtongxiao External Application on Joint Function for Elderly Patients with Acute Gouty Arthritis

作　　者：李莉[1] 刘利利[1] 任艳梅[2] 李红霞[1] LI Li;LIU LiLi;REN Yanmei(Nephropathy Department,Cang-zhou Integrated Chinese and Western Medicine Hospital,Cangzhou Hebei 061001,China;Pharmacy Department,Cangzhou Integrated Chinese and Western Medicine Hospital,Cangzhou Hebei 061001,China)

机构地区：[1]河北省沧州中西医结合医院肾病科,河北沧州061001 [2]河北省沧州中西医结合医院药剂科,河北沧州061001

出　　处：《四川中医》2021年第6期138-142,共5页Journal of Sichuan of Traditional Chinese Medicine

基　　金：沧州市重点研发计划项目(编号:172302184)。

摘　　要：目的:观察清利活血解毒汤联合肿痛消外敷对老年急性痛风性关节炎关节功能的影响。方法:选择本院2018年1月~2020年1月收治的136例急性痛风性关节炎老年患者作为研究对象,用随机数表法将所有患者分为观察组(n=68)和对照组(n=68)。对照组进行常规西医治疗,观察组在对照组的基础上使用清利活血解毒汤联合肿痛消外敷进行治疗。观察两组临床疗效,记录治疗前1d和治疗后2周两组中医症候积分和实验室指标[血尿酸(UA)、红细胞沉降率(ESR)、白介素-1β(IL-1β)、白介素-6(IL-6)]水平,记录治疗前1d和治疗后3、7、14d两组关节功能评分,记录治疗后两组不良反应发生情况。结果:治疗后,观察组(86.76%)治疗总有效率明显高于对照组(75.00%),P<0.05;治疗后,两组活动受限、关节疼痛、关节压痛、关节红肿等积分均有所下降(P<0.05);治疗后,与对照组相比,观察组各项积分均较低(P<0.05);治疗后3、7、14d,两组关节功能评分均呈现下降趋势(P<0.05);治疗后3、7、14d,与对照组相比,观察组关节功能评分均比较低(P<0.05);治疗后,两组UA、ESR、IL-1β、IL-6水平均有所下降(P<0.05);治疗后,与对照组相比,观察组UA、ESR、IL-1β、IL-6水平均比较低(P<0.05);治疗后,两组不良反应发生情况无明显差异(P>0.05)。结论:清利活血解毒汤联合肿痛消外敷治疗老年急性痛风性关节炎能够改善患者临床症状、关节功能和相关实验室指标水平,疗效较好,并且不良反应较少,安全性高,具有推广价值。Objective: To study the effect of Qingli Huoxue Jiedu Decoction combined with Zhongtongxiao external application on the joint function for elderly patients with acute gouty arthritis. Methods: 136 elderly patients with acute gouty arthritis in our hospital from January 2018 to January 2020 were selected as the research objects, and all patients were randomly divided into an observation group(n=68) and a controlled group(n=68). The controlled group was treated with conventional western medicine, and the observation group was treated with Qingli Huoxue Jiedu Decoction combined with Zhongtongxiao external application on the basis of the controlled group. Observed the clinical efficacy of the two groups, record the TCM symptom score and laboratory indexes [blood uric acid(UA),erythrocyte sedimentation rate(ESR),interleukin-1β(IL-1β),interleukin-6(IL-6)] levels of the two groups 1 day before treatment and 2 weeks after treatment, recorded the joint function score of the two groups 1 day before treatment and 3,7,14 days after treatment, and record the occurrence of adverse reactions of the two groups after treatment. Results: After treatment, the total effective rate of the observation group(86.76%) was higher than that of the controlled group(75.00%),P<0.05. After treatment, the scores of limited activity, joint pain, joint tenderness, joint redness and swelling of the two groups were decreased(P<0.05). After treatment, compared with the controlled group, the scores of the observation group were lower(P<0.05). After 3,7 and 14 days of treatment, the joint function scores of the two groups showed a downward trend(P<0.05). 3,7,14 days after treatment, compared with the controlled group, the joint function score of the observation group was lower(P<0.05). After treatment, UA, ESR,IL-1β and IL-6 levels in the two groups decreased(P<0.05). After treatment, UA, ESR,IL-1β and IL-6 levels in the observation group were lower than those in the controlled group(P<0.05). After treatment, there was no significant difference in

关 键 词：急性痛风性关节炎 清利活血解毒汤 肿痛消外敷 关节功能 中医症候积分 

分 类 号：R589.7[医药卫生—内分泌]