复方嗜酸乳杆菌片联合乳果糖对糖尿病便秘患者脑肠肽水平的影响  

Effect of compound Lactobacillus acidophilus tablet combined with lactulose on brain and gut peptide levels in patients with diabetes

作　　者：李亮 王君福 LI Liang;WANG Jun-fu(Medical Department,Taizhou Cancer Hospital of Zhejiang Province,Taizhou,Zhejiang 317502,China;不详)

机构地区：[1]浙江省台州市肿瘤医院内科,浙江台州317502 [2]浙江省台州市肿瘤医院检验科,浙江台州317502

出　　处：《中国微生态学杂志》2021年第6期683-685,共3页Chinese Journal of Microecology

摘　　要：目的探讨复方嗜酸乳杆菌片联合乳果糖对糖尿病便秘患者脑肠肽水平的影响。方法选择2018年1月-2019年8月在我院内科门诊治疗的糖尿病便秘患者92例,随机分为观察组和对照组各46例。两组均予建立良好生活习惯、饮食调整、适当运动、排便锻炼及药物控制血糖等基础治疗。对照组在此基础上加乳果糖口服液15 mL/次,2次/d,口服。观察组在对照组基础上加复方嗜酸乳杆菌片1.0 g/次,3次/d,温开水服用。两组均连用12周。观察两组治疗前后血清脑肠肽[一氧化氮(NO)、P物质(SP)和血管活性肠肽(VIP)]水平及便秘症状评分的变化,并比较其临床效果。结果治疗12周后,两组血清NO和VIP水平及Wexner便秘症状评分较前下降,血清SP水平较前上升(P<0.05),且治疗后观察组变化幅度较对照组明显(P<0.05)。观察组临床总有效率为95.7%,明显优于对照组的82.6%(χ^(2)=4.040,P=0.046)。结论复方嗜酸乳杆菌片联合乳果糖治疗糖尿病便秘患者的效果确切,其作用机制可能是通过调节脑肠肽分泌,减少NO和VIP分泌,促进SP分泌,从而提高结肠传输功能。Objective To observe the effect of compound Lactobacillus acidophilus tablet combined with lactulose on brain and gut peptide levels in patients with diabetes.Methods Ninety-two patients with diabetes and constipation who were treated in the outpatient department from January 2018 to August 2019 were randomly divided into observation group or control group,46 cases each.Both groups were given the same basic treatments.The patients in control group were additionally given lactulose oral liquid,15 mL bid,while those in observation group were given Lactobacillus acidophilus tablet,1.0 g tid,for 12 weeks.The levels of serum brain-gut peptides[nitric oxide(NO),substance P(SP)and vasoactive intestinal peptide(VIP)]and constipation score were observed before and after treatment,and clinical effects were compared between groups.Results After treatment,the serum levels of NO,VIP and Wexner constipation scores in both groups were significantly lower,while that of SP was significantly higher(P<0.05);the changes in observation group were greater than in control group(P<0.05).The total clinical efficiency rate in observation group(95.7%)was significantly higher than that in control group(82.6%)(χ^(2)=4.040,P=0.046).Conclusion Compound Lactobacillus acidophilus tablet combined with lactulose is effective in treating patients with diabetes and constipation.Its mechanism of action may be improving colonic transmission through regulating brain and intestinal peptide secretion,reducing NO and VIP secretion,and promoting SP secretion.

关 键 词：糖尿病便秘 复方嗜酸乳杆菌片 乳果糖 脑肠肽 

分 类 号：R378[医药卫生—病原生物学]