急性脑梗死患者冠脉病变程度与血清可溶性E-选择素、高敏C反应蛋白水平的相关性  

Correlation between the Degree of Coronary Artery Lesions and Serum SES and Hs-CRP Levels in Patients with Acute Cerebral Infarction

作　　者：朱维春 ZHU Wei-chun(Department of Neurology,Leizhou People's Hospital,Leizhou,Guangdong,524200,China)

机构地区：[1]雷州市人民医院神经内科,广东雷州524200

出　　处：《黑龙江医学》2021年第15期1587-1589,共3页Heilongjiang Medical Journal

基　　金：湛江市科技划项目(2020B01452)。

摘　　要：目的:探讨急性脑梗死(ACI)患者冠脉病变程度与血清可溶性E-选择素(SES)、高敏C反应蛋白(hs-CRP)水平的相关性。方法:回顾性收集雷州市人民医院2018年5月-2020年5月接诊的175例ACI患者的资料,均行冠状动脉造影,采用酶联免疫吸附法检测血清SES、hs-CRP水平,比较不同冠脉病变患者血清SES、hs-CRP水平,并分析Gensini积分与血清SES、hs-CRP水平的相关性。结果:单、双、三支组Gensini积分均高于ACI组,双、三支组Gensini积分及血清SES、hs-CRP水平均高于单支组、ACI组,三支组Gensini积分及血清SES、hs-CRP水平均高于双支组,差异均有统计学意义(P<0.05);Gensini积分与血清SES、hs-CRP水平均呈正相关(P<0.05);SES、hs-CRP与ln(Gensini积分)独立相关(P<0.05)。结论:ACI患者冠脉病变程度与血清SES、hs-CRP水平显著相关,或可作为ACI患者危险分层的预测因子。Objective: To investigate the correlation between the degree of coronary artery lesions in patients with acute cerebral infarction(ACI) and serum levels of soluble E-selectin(SES) and high-sensitivity C-reactive protein(hs-CRP). Methods:The data of 175 ACI patients admitted to the hospital from May 2018 to May 2020 were collected retrospectively. Coronary angiography was performed on all patients. The serum SES and hs-CRP levels were detected by enzyme Linked immunosorbeit assay(ELISA) to compare the serum SES and hs-CRP levels of patients with different coronary lesions, and the correlation between Gensini score and the serum SES and hs-CRP levels was analyzed. Results: Gensini scores and serum SES and hs-CRP levels of the onevessel, two-vessel and three-vessel group were all higher than those of the ACI group, and the Gensini scores and serum SES and hs-CRP levels of the two-vessel and three-vessel group were all higher than those of the one-vessel group and ACI group, with statistically significant differences(P<0.05). The levels of Gensini score and serum SES and hs-CRP in the three-vessel group were higher than those in the two-vessel group, and the differences were statistically significant(P<0.05). Gensini score was positively correlated with serum SES and hs-CRP levels(P<0.05). SES and hs-CRP were independently correlated with ln(Gensini score)(P<0.05). Conclusion: The degree of coronary artery lesions in ACI patients was significantly correlated with serum SES and hs-CRP levels, it may be used as a predictor of risk stratification in ACI patients.

关 键 词：急性脑梗死 冠脉病变程度 可溶性E-选择素 高敏C反应蛋白 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]