重度子痫前期合并胎儿生长受限的凝血指标、脐血流S/D值以及母婴结局分析  

Analysis of Coagulation Index, Umbilical Blood Flow S/D Value and Maternal and Infant Outcomes in Severe Preeclampsia Complicated with Fetal Growth Restriction

作　　者：仲艳敏 ZHONG Yan-min(Obstetrics and Gynecology,Guanghou Womenand Children Medical Center,Guangzhou,Guangdong,510000,China)

机构地区：[1]广州市妇女儿童医疗中心妇产科,广东广州510000

出　　处：《黑龙江医学》2021年第15期1595-1597,共3页Heilongjiang Medical Journal

摘　　要：目的:探究重度子痫前期合并胎儿生长受限的D-二聚体、蛋白S、蛋白C、抗凝血酶Ⅲ、脐血流S/D值以及母婴结局。方法:在2019年1月-2020年10月时间段内,选择在广州市妇女儿童医疗中心产科进行治疗和分娩的72例重度子痫前期患者为研究对象,选择回顾分析法对其临床资料进行分析,将36例合并胎儿生长受限的患者纳入实验组,另外36例未合并胎儿生长受限的患者纳入对照组,分析患者脐血流S/D值和D-二聚体、蛋白S、蛋白C、抗凝血酶Ⅲ、母婴结局详情。结果:两组D-二聚体、抗凝血酶Ⅲ、脐血流S/D值、蛋白S水平对比差异显著(P<0.05);两组患者的蛋白C水平、分娩孕周、住院天数对比无明显差异(P>0.05);两组患者HELLP综合征、急性左心衰、胎盘早剥、腹水、胸水、视网膜水肿发生率以及新生儿窒息、黄疸、贫血发生率对比差异较小(P>0.05);两组的胎儿窘迫终止妊娠率以及体重对比差异较大(P<0.05)。结论:在重度子痫前期合并胎儿生长受限的患者中,患者呈高凝状态且增加母婴不良结局发生率,通过脐血流S/D值和D-二聚体、蛋白S、蛋白C水平有助于判断疾病严重程度。Objective:To explore the D-dimer,protein S,protein C,antithrombinⅢ,umbilical blood flow S/D value and mater-nal and infant outcomes in severe preeclampsia with fetal growth restriction.Methods:From January 2019 to October 2020,72 pa-tients with severe preeclampsia who were treated and delivered in the hospital were selected as the research objects.The clinicaldata were analyzed by retrospective analysis method.36 patients with fetal growth restriction were included in the experimentalgroup,and the other 36 patients without fetal growth restriction were included in the control group.Umbilical blood flow S/D value,D-dimer,protein S,protein C,antithrombinⅢ,details of maternal and infant outcomes were analyzed.Results:There were statisti-cally significant differences in D-dimer,antithrombinⅢ,umbilical blood flow S/D value and protein S level between the twogroups(P<0.05).There were no statistically significant differences in protein C level,gestational weeks of delivery and hospitaliza-tion days between the two groups(P>0.05).The two groups of patients had relatively small differences in the incidence of HELLPsyndrome,acute left heart failure,placental abruption,ascites,pleural effusion,retinal edema,as well as neonatal asphyxia,jaun-dice,and anemia(P>0.05).There was a big difference in the pregnancy termination rate and weight of fetal distress between thetwo groups(P<0.05).Conclusion:In patients with severe preeclampsia combined with fetal growth restriction,the patients are ina hypercoagulable state and increases the incidence of adverse maternal and infant outcomes.Through the umbilical blood flow S/Dvalue and D-dimer,protein S,and protein C levels helps to judge the severity of the disease.

关 键 词：重度子痫前期 胎儿生长受限 D-二聚体 抗凝血酶III指标 母婴结局 

分 类 号：R714.431[医药卫生—妇产科学]