STAT在皮肤病发病中作用的研究进展  

Research progress on the role of STAT in the pathogenesis of dermatosis

作　　者：周琼艳[1] 林薇[2] 许素玲[1] 赵可喻 ZHOU Qiong-yan;LIN Wei;XU Su-ling;ZHAO Ke-yu(Department of Dermatology,the Affiliated Hospital of Medical School,Ningbo University,Ningbo 315020;Department of Pharmacy,the Affiliated Hospital of Medical School,Ningbo University,Ningbo 315020;School of Medicine, Ningbo University, Ningbo 315211, China)

机构地区：[1]宁波大学医学院附属医院皮肤科,浙江宁波315020 [2]宁波大学医学院附属医院药剂科,浙江宁波315020 [3]宁波大学医学院,浙江宁波315211

出　　处：《基础医学与临床》2021年第8期1205-1209,共5页Basic and Clinical Medicine

基　　金：浙江省实验动物科技计划项目(2018C37101);浙江省公益技术研究计划/实验动物项目(LGD19H110001);浙江省自然科学基金项目(LY18H110003);浙江省医药卫生重大科技计划项目(WKJ-ZJ-2012)。

摘　　要：信号传导和转录激活因子(STAT)是有转录活性的蛋白,参与特应性皮炎、银屑病、皮肤肿瘤等多种皮肤病发病、皮损形成,与皮肤病严重程度相关,不同STAT在皮肤病中作用途径并不相同。STAT通过调控细胞信号传导,影响下游因子表达,发挥生物学效应,深入研究STAT表达水平及靶向基因,探讨其与皮肤病之间的关系,有助于发现皮肤病潜在的治疗靶点。Signal transducer and activator of transcription(STAT)proteins with transcriptional activity,which are involved in the pathogenesis and formation of skin lesions of atopic dermatitis,psoriasis,skin tumors and other dermatosis,and are related to the severity of dermatosis.Different STAT has different pathways in dermatosis.STAT regulate cell signal transduction,affect the expression of downstream factors,and exert biological effects.Further study of STAT expression level and targeted genes to explore the relationship between STAT and dermatosis will help to find potential therapeutic targets for dermatosis.

关 键 词：信号传导和转录激活因子(STAT) 皮肤病 通路 

分 类 号：R751[医药卫生—皮肤病学与性病学]