自然杀伤细胞在EB病毒感染中的作用  

The impact of natural killer cells in epstein-barr virus infection

作　　者：范泽颖 赵翔宇[1] FAN Zeying;ZHAO Xiangyu(Department of Hematology,Peking University People´s Hospital&Peking University Institute of Hematology,Beijing 100044,China)

机构地区：[1]北京大学人民医院血液科北京大学血液病研究所,北京100044

出　　处：《中国研究型医院》2021年第4期58-63,共6页Chinese Research Hospitals

基　　金：国家自然科学基金面上项目(81870140);北京市科技计划项目(Z171100001017098)。

摘　　要：异基因造血干细胞移植(Allo-HSCT)是治疗血液系统疾病有效的治疗手段,而感染是影响移植后患者生存的主要因素,EB病毒(EBV)在90%以上健康人的B淋巴细胞(简称B细胞)中潜伏感染,当患者行Allo-HSCT或因其他情况导致机体免疫力低下时,EBV可被重新激活,所引起相应疾病的病死率较高。自然杀伤细胞(NK)是一类具备抗病毒功能的天然免疫细胞,其作为Allo-HSCT后最早恢复的免疫细胞,在移植后早期抗病毒感染中发挥着重要作用。研究表明NK细胞在EBV的原发感染或复发感染(复燃),以及不同类型的EBV感染中均发挥作用,但有关机制的研究相对较少。本文中就NK细胞在EBV感染中的作用进行综述。Allogeneic stem cell transplantation(Allo-HSCT)is an effective treatment for blood system diseases,and infection is the main factor affecting the survival of patients after transplantation.The Epstein-barr virus(EBV)is latently infected in the B lymphocytes(abbreviated as B cell)of more than 90%of healthy people.When the patient undergoes Allo-HSCT,or the body´s immunity is weakened due to other conditions,EBV can be reactivated,causing a higher mortality rate of the corresponding disease.Natural killer cells(NK cells)are a type of innate immune cells with antiviral function.They are the earliest immune cells recovered after Allo-HSCT and play an important role in the early antiviral infection after transplantation.Studies have shown that NK cells play a role in EBV primary infection or EBV reactivation and different types of EBV infection,but there are relatively few studies on the mechanism.This article reviews the role of NK cells in EBV infection.

关 键 词：杀伤细胞 天然 爱泼斯坦巴尔病毒感染 感染控制 

分 类 号：R511[医药卫生—内科学]