Living Bacterial Microneedles for Fungal Infection Treatment  

作　　者：Fengyuan Wang Xiaoxuan Zhang Guopu Chen Yuanjin Zhao 

机构地区：[1]Department of Burns&Plastic Surgery,Institute of Translational Medicine,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China [2]Department of Dermatology,Zhongda Hospital,Southeast University,Nanjing 210009,China [3]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

出　　处：《Research》2020年第1期446-454,共9页研究（英文）

基　　金：This work was supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060 and 61927805);the Natural Science Foundation of Jiangsu(BE2018707 and BK20190353).

摘　　要：Fungal infections are everlasting health challenges all over the world,bringing about great financial and medical burdens.Here,inspired by the natural competition law of beneficial bacteria against other microbes,we present novel living microneedles(LMNs)with functionalized bacteria encapsulation for efficient fungal infection treatment.The chosen beneficial bacterial components,Bacillus subtilis(B.subtilis),which are naturally found on the human skin and widely used for food processing,can get nutrients from the skin and escape from the immune system with the help of microneedles.Besides,the encapsulated B.subtilis can continuously produce and secrete various potential antifungal agents which can directly bind to fungal cell surfaceassociated proteins and destruct the cell membranes,thus avoiding drug resistance.After immobilization in the LMNs,the bacteria can stay within the LMNs without invasion and the encapsulated bacteria together with microneedles can be removed after application.Thus,the side effects,especially the risk for subsequent bacterial infections,are controlled to a minimum to ensure security.In addition,strong penetrability of the microneedles enhances penetration of antifungal agents,and their heights can be adjusted according to the infected depth to acquire better therapeutic effects.These features make the LMNs potentially valuable for clinical applications.

关 键 词：INVASION bringing removed 

分 类 号：R519[医药卫生—内科学]