Smart Microneedles for Therapy and Diagnosis  

作　　者：Xiaoxuan Zhang Yuetong Wang Junjie Chi Yuanjin Zhao 

机构地区：[1]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [2]Department of Rheumatology and Immunology,Institute of Translational Medicine,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China

出　　处：《Research》2020年第1期1295-1320,共26页研究（英文）

基　　金：This work was supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060 and 61927805);the Natural Science Foundation of Jiangsu(BE2018707).

摘　　要：Microneedles represent a cutting-edge and idea-inspiring technology in biomedical engineering,which have attracted increasing attention of scientific researchers and medical staffs.Over the past decades,numerous great achievements have been made.The fabrication process of microneedles has been simplified and becomes more precise,easy-to-operate,and reusable.Besides,microneedles with various features have been developed and the microneedle materials have greatly expanded.In recent years,efforts have been focused on generating smart microneedles by endowing them with intriguing functions such as adhesion ability,responsiveness,and controllable drug release.Such improvements enable the microneedles to take an important step in practical applications including household drug delivery devices,wearable biosensors,biomedical assays,cell culture,and microfluidic chip analysis.In this review,the fabrication strategies,distinctive properties,and typical applications of the smart microneedles are discussed.Recent accomplishments,remaining challenges,and future prospects are also presented.

关 键 词：SMART ACCOMPLISHMENT enable 

分 类 号：R318[医药卫生—生物医学工程]