胺碘酮和含碘造影剂致甲状腺功能障碍的机制和临床管理  

Mechanism and Clinical Management of Thyroid Dysfunction Induced by Amiodarone and Iodinated Contrast

作　　者：徐佩 关海霞[1,2] XU Pei;GUAN Haixia(Department of Endocrinology and Metabolism,the National Health Commission(NHC)Key Laboratory of Diagnosis and Treatment of Thyroid Diseases,the First Hospital of China Medical University,Shenyang 110001,China;Department of Endocrinology,Guangdong Provincial People′s Hospital/Guangdong Academy of Medical Sciences,Guangzhou 510080,China)

机构地区：[1]中国医科大学附属第一医院内分泌科卫健委(共建)甲状腺疾病重点实验室,沈阳110001 [2]广东省医学科学院广东省人民医院内分泌科,广州510080

出　　处：《医学综述》2021年第14期2808-2813,共6页Medical Recapitulate

基　　金：国家自然科学基金(81870538)。

摘　　要：在临床实践中,胺碘酮和含碘造影剂等因素均可引发医源性碘过量,并可导致甲状腺功能障碍,但两者的理化特征、代谢特点、适用人群存在差异,且其所致甲状腺功能障碍的发生机制和临床特点并不完全一致,因此诊断和治疗存在差异。加深对胺碘酮和含碘造影剂所致甲状腺功能障碍的机制和临床管理等的认识,有助于明确医源性甲状腺功能障碍的诊治方法,并为制订医源性甲状腺功能障碍的预防策略提供方向。In clinical practice,amiodarone and iodine containing contrast agents can cause iatrogenic iodine excess and lead to thyroid dysfunction.However,there are differences in their physical and chemical characteristics,metabolic characteristics and applicable population,and the mechanism and clinical characteristics of thyroid dysfunction are not completely consistent,so there are differences in the diagnosis and treatment.To deepen the understanding of the mechanism and clinical management of thyroid dysfunction caused by amiodarone and iodine containing contrast media will help to clarify the diagnosis and treatment of iatrogenic thyroid dysfunction,and provide direction for the formulation of prevention strategies of iatrogenic thyroid dysfunction.

关 键 词：甲状腺功能减退 甲状腺毒症 碘 胺碘酮 含碘造影剂 

分 类 号：R581[医药卫生—内分泌]