帕拉米韦和炎琥宁加奥司他韦治疗流感病毒感染患儿的效果分析  被引量:4

Analysis of the Effect of Pramivir and Yanhuning Combined with Oseltamivir in the Treatment of Children with Influenza Virus Infection

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作  者:陈洁静[1] 郑祖芬[1] Chen Jiejing;Zheng Zufen(Department of Pediatrics,Sihui People's Hospital,Zhaoqing 526200)

机构地区:[1]四会市人民医院儿科,肇庆526200

出  处:《数理医药学杂志》2021年第8期1189-1191,共3页Journal of Mathematical Medicine

摘  要:目的:探讨帕拉米韦和炎琥宁加奥司他韦治疗流感病毒感染患儿的效果。方法:按照简单随机化法将某院2019年6月~2020年6月65例流感病毒感染患儿分为对照组和观察组,对照组35例给予炎琥宁加奥司他韦治疗,观察组30例给予帕拉米韦氯化钠注射液治疗,两组均连续治疗5~7d,对比两组临床疗效、治疗前后的免疫功能(血清IgA、IgG、IgM)及血清CRP、SAA、ICAM-1、IL-6水平变化。结果:观察组患者临床总有效率为96.67%,高于对照组的62.86%(P<0.05);与治疗前相比,治疗后两组患者的血清IgA、IgG、IgM水平均升高,观察组高于对照组(P<0.05);与治疗前相比,治疗后两组患者的血清CRP、SAA、ICAM-1、IL-6水平均降低,观察组低于对照组(P<0.05)。结论:帕拉米韦氯化钠注射液可有效缓解流感病毒感染患儿的临床症状,提高治疗效果,提高机体抵抗力,改善免疫功能,减轻机体的炎症反应。Objective:To investigate the effect of pramivir and Yanhuning combined with oseltamivir in the treatment of children with influenza virus infection.Methods:According to the simple randomized method,65 children with influenza virus infection in a hospital from June 2019 to June 2020 were divided into control group(35 cases,Yanhuning combined with oseltamivir)and observation group(30 cases,paramivir sodium chloride injection).Both groups were treated for 5-7 days.The clinical efficacy,immune function(serum IgA,IgG,IgM)and serum CRP,SAA,ICAM-1,IL-6 levels before and after treatment were compared between the two groups.Results:The total effective rate of the observation group was 96.67%,which was higher than 62.86%of the control group(P<0.05).Compared with before treatment,the serum IgA,IgG and IgM levels of the two groups were increased after treatment,and the observation group was higher than the control group(P<0.05).Compared with before treatment,the levels of serum CRP,SAA,ICAM-1 and IL-6 in the two groups were decreased after treatment,and those in the observation group were lower than those in the control group(P<0.05).Conclusion:Paremivir sodium chloride injection can effectively relieve the clinical symptoms of children with influenza virus infection,improve the therapeutic effect,improve the body resistance,improve the immune function,and reduce the body's inflammatory reaction.

关 键 词:流感病毒感染 帕拉米韦 炎琥宁 奥司他韦 

分 类 号:R720.5[医药卫生—儿科]

 

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