奥利司他治疗肥胖伴多囊卵巢综合征的效果观察  

Observation on The Effect of Orlistat In The Treatment of Obesity With Polycystic Ovary Syndrome

作　　者：闵珊[1] 陈虹燕[1] Min Shan;Chen Hongyan(Department of Gynecology and Endocrinology,Guangzhou Panyu Hospital of Traditional Chinese Medicine,Guangzhou 511400,China)

机构地区：[1]广州市番禺区中医院内分泌科,广东广州511400

出　　处：《实用妇科内分泌电子杂志》2021年第7期36-40,共5页Electronic Journal of Practical Gynecological Endocrinology

基　　金：广东省中医药局科研课题(编号20181218)。

摘　　要：目的探讨肥胖伴多囊卵巢综合征应用奥利司他治疗的临床效果。方法选取60例肥胖伴多囊卵巢综合征患者,按照随机数字表法分为对照组与试验组,每组30例。对照组予以炔雌醇环丙孕酮片治疗,试验组在对照组基础上予以奥利司他治疗,比较两组治疗前后血脂、血糖指标、性激素水平、体征及临床症状、排卵率、妊娠率。结果治疗前,两组患者甘油三脂、总胆固醇、胰岛素抵抗指数(HOMA-IR)、空腹胰岛素及空腹血糖指标比较,差异无统计学意义(P>0.05);治疗后,两组甘油三脂、总胆固醇、HOMA-IR、空腹胰岛素及空腹血糖指标均低于各组治疗前,且试验组明显低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者睾酮、雌二醇、卵泡雌激素、促黄体生成素水平比较,差异无统计学意义(P>0.05);治疗后,两组睾酮、雌二醇、卵泡雌激素、促黄体生成素水平均显著低于治疗前,且试验组显著低于对照组,差异有统计学意义(P<0.05)。治疗前,两组瘦素、脂联素、内脂素比较,差异无统计学意义(P>0.05);治疗后,两组脂联素显著高于治疗前,瘦素、内脂素显著低于治疗前,且试验组脂联素显著高于对照组,瘦素、内脂素显著低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者卵巢体积、多毛评分、腰臀比、体质量指数指标比较,差异无统计学意义(P>0.05);治疗后,两组卵巢体积小于治疗前,多毛评分、腰臀比、体质量指数指标均显著低于治疗前,且试验组卵巢体积小于对照组,多毛评分、腰臀比、体质量指数指标均显著低于对照组,差异具有统计学意义(P<0.05)。试验组排卵率为93.33%,妊娠率为80.00%,均显著高于对照组的70.00%、53.33%,差异具有统计学意义(P<0.05)。结论肥胖伴多囊卵巢综合征患者采用奥利司他进行治疗能够有效降低其血糖和血脂水平,改善性激素水平,在一定程度上提�Objective To investigate the clinical effect of orlistat in the treatment of obesity with polycystic ovary syndrome.Methods 60 obese patients with polycystic ovary syndrome were selected and divided into control group and experimental group according to random number table method,with 30 cases in each group.The control group was treated with eparylestradiol cyproterone tablets,and the experimental group was treated with orlistat on the basis of the control group.The blood lipid,blood glucose,sex hormone levels,signs and clinical symptoms,ovulation rate and pregnancy rate were compared between the two groups before and after treatment.Results Before treatment,there were no significant differences in triglyceride,total cholesterol,insulin resistance index(HOMA-IR),fasting insulin and fasting blood glucose indexes between 2 groups(P>0.05).After treatment,the indexes of triglyceride,total cholesterol,HOMA-IR,fasting insulin and fasting blood glucose in both groups were before treatment,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of testosterone,estradiol,follicular estrogen and luteinizing hormone between 2 groups(P>0.05).After treatment,the levels of testosterone,estradiol,follicular estrogen and luteinizing hormone in 2 groups were significantly lower than before treatment,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in leptin,adiponectin and endolipid between the two groups(P>0.05).After treatment,adiponectin in 2 groups was significantly higher than before treatment,while leptin and endolipid were significantly lower than before treatment,and adiponectin in test group was significantly higher than control group,while leptin and endolipid were significantly lower than control group,the difference was statistically significant(P<0.

关 键 词：多囊卵巢综合征 肥胖 奥利司他 

分 类 号：R711.75[医药卫生—妇产科学]