抵当汤加减治疗慢性肾脏病脾肾气虚兼血瘀证临床研究  

Clinical Study on the Treatment of Chronic Kidney Disease with Spleen-Kidney Qi Deficiency Combined with Blood Stasis Syndrome by Modified Resistance Decoction

作　　者：张敏[1,2] 方立明[1,2] 韦玲[1,2] 谢圣芳[1,2] ZHANG Min;FANG Li-ming;WEI Ling;XIE Sheng-fang(Jiangsu Provincial Hospital of Integrated Traditional and Western Medicine,Nanjing,Jiangsu,China,210028;Jiangsu Academy of Traditional Chinese Medicine,Nanjing,Jiangsu,China,210028)

机构地区：[1]南京中医药大学附属中西医结合医院,江苏南京210028 [2]江苏省中医药研究院,江苏南京210028

出　　处：《河南中医》2021年第8期1174-1177,共4页Henan Traditional Chinese Medicine

基　　金：第三批江苏省中医临床人才研修项目{苏中医科教[2017]18号}。

摘　　要：目的:观察抵当汤加减治疗慢性肾脏病(chronic kidney disease,CKD)脾肾气虚兼血瘀证的临床疗效。方法:将120例CKD患者按照随机数字表法分为对照组和治疗组,每组各60例。对照组给予常规西医治疗,治疗组在对照组的基础上联合抵当汤加减治疗。比较两组患者的临床疗效及治疗前后中医证候积分、肾功能指标变化情况。结果:治疗组有效率为78.3%,对照组有效率为51.7%,两组有效率比较,差异具有统计学意义(P<0.05)。对照组患者治疗后倦怠乏力、面色晦暗、腰痛等中医证候积低于本组治疗前,差异具有统计学意义(P<0.05),但腰膝酸软、食少纳呆、气短懒言症状未见改善,差异无统计学意义(P>0.05)。治疗组治疗后各项中医证候积分低于本组治疗前及对照组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗后肾功能指标低于本组治疗前,且治疗后治疗组低于对照组,差异具有统计学意义(P<0.05)。结论:抵当汤加减治疗CKD,可改善患者临床症状及肾功能。Objective:To observe the clinical curative effect of Modified Resistance Decoction on chronic kidney disease(CKD)with spleen-kidney qi deficiency combined with blood stasis syndrome.Methods:A total of 120 patients with CKD were randomly divided into the control group and the treatment group,with 60 cases in each group.The control group was treated with conventional western medicine,and the treatment group was treated with Modified Resistance Decoction on the basis of the control group.The clinical efficacy,TCM syndrome score and renal function indexes of the two groups were compared before and after treatment.Results:The effective rate of the treatment group was 78.3%,and that of the control group was 51.7%.The difference between the two groups was statistically significant(P<0.05).After treatment,the symptoms of fatigue,dark complexion and low back pain in the control group were lower than those of the same group before treatment,and all the differences were statistically significant(P<0.05),but the symptoms of soreness and weakness of waist and knee,lack of food,shortness of breath and lazy speech did not improve,and all the differences were not statistically significant(P>0.05).The TCM syndrome scores of the treatment group after treatment were lower than those of the same group before treatment and those of the control group after treatment,and the difference was statistically significant(P<0.05).The renal function indexes of the two groups after treatment were lower than those of the same group before treatment,and the above indexes of the treatment group after treatment were lower than those of the control group,and all the differences were statistically significant(P<0.05).Conclusion:In terms of CKD,Modified Resistance Decoction can improve the clinical symptoms and renal function of the patients.

关 键 词：慢性肾脏病 脾肾气虚兼血瘀证 抵当汤 中西医结合疗法 《金匮要略》 张仲景 

分 类 号：R277.592[医药卫生—中医学]