甘露消毒丹加减治疗传染性单核细胞增多症32例  

Thirty-Two Cases of Infectious Mononucleosis Treated with Modified Sweet Dew Toxin-Removing Elixir

作　　者：张景阳 ZHANG Jing-yang(Xinmi Maternity and Infant Health Institute,Xinmi,Henan,China,452370)

机构地区：[1]新密市妇幼保健院,河南新密452370

出　　处：《河南中医》2021年第8期1214-1218,共5页Henan Traditional Chinese Medicine

基　　金：郑州市科技攻关项目(20190213179)。

摘　　要：目的:观察甘露消毒丹加减治疗传染性单核细胞增多症(infectious mononucleosis,IM)的临床疗效。方法:选取2019年1月至2020年5月本院治疗的IM患儿64例,按照随机数字表法分为治疗组和对照组,每组32例。对照组给予阿昔洛韦注射液治疗及对症支持治疗,治疗组在对照组治疗的基础上给予甘露消毒丹加减治疗。结果:治疗组发热缓解时间、咽峡炎缓解时间、颈部淋巴结肿大缓解时间、肝肿大缓解时间、脾肿大改善时间短于对照组,差异有统计学意义(P<0.05);治疗组治疗后中医证候积分低于对照组,差异有统计学意义(P<0.05);治疗组T细胞亚群(CD4~+/CD8~+)比值高于对照组,差异有统计学意义(P<0.05);两组患儿治疗后异常淋巴细胞改变较治疗前降低,且治疗组低于对照组,差异有统计学意义(P<0.05);治疗组治疗后C反应蛋白水平低于对照组,差异有统计学意义(P<0.05);治疗组有效率为91%,对照组有效率为78%,治疗组有效率高于对照组,差异有统计学意义(P<0.05)。结论:甘露消毒丹加减可以有效改善IM患儿的临床症状及中医证候,缩短病程。Objective:To observe the clinical curative effect of Modified Sweet Dew Toxin-Removing Elixir on infectious mononucleosis(IM).Methods:A total of 64 children with IM treated in our hospital from January 2019 to may 2020 were selected and randomly divided into the treatment group and the control group,with 32 cases in each group.The control group was given Acyclovir Injection and symptomatic support treatment,and the treatment group was given Modified Sweet Dew Toxin-Removing Elixir on the basis of the control group.Results:The remission time of fever,angina,cervical lymphadenopathy,hepatomegaly and splenomegaly in the treatment group were shorter than that in the control group,and each difference was statistically significant(P<0.05).After treatment,the TCM syndrome score of the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05);The ratio of CD4+/CD8+in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the abnormal lymphocyte changes of the two groups were lower than those of the same group before treatment,and the abnormal lymphocyte change of the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the level of C-reactive protein in the treatment group was lower than that in the control group,and the difference was statistically significant(P<0.05).The effective rate of the treatment group was 91%,which was higher than that of the control group:78%,and the difference was statistically significant(P<0.05).Conclusion:Modified Sweet Dew Toxin-Removing Elixir can effectively improve the clinical symptoms and TCM syndromes of IM children and shorten the course of disease.

关 键 词：传染性单核细胞增多症 EB病毒 阿昔洛韦注射液 甘露消毒丹 中西医结合疗法 

分 类 号：R272.925.1[医药卫生—中医儿科学]