中医药抗肝纤维化机制研究进展  

Research Progress of Anti Hepatic Fibrosis Mechanism of TCM

作　　者：符燕青 农小欣 苏晓文 庞秋琳 王振常 FU Yan-qing;NONG Xiao-xin;SU Xiao-wen;PANG Qiu-lin;WANG Zhen-chang(Guangxi University of Chinese Medicine,Nanning,Guangxi,China,530000;Guangxi International Zhuang Medical Hospital,Nanning,Guangxi,China,530000)

机构地区：[1]广西中医药大学,广西南宁530000 [2]广西国际壮医医院,广西南宁53000

出　　处：《河南中医》2021年第8期1256-1261,共6页Henan Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81660745)。

摘　　要：目前,中医药抗纤维化的机制主要包括:抑制肝星状细胞的激活,减少肝细胞损伤;抑制细胞外基质(extracellular matrix,ECM)合成、降解;抗氧化、抑制炎症等。但研究存在以下不足:临床观察样本量较少,缺乏统一的治疗标准;机制研究主要以动物实验研究为主,临床实验研究较少,研究尚不成熟。今后,需进一步加强基础及临床研究,拓展基础研究理念,从肠道菌群、外泌体等方面进行机制研究;开展高质量的临床研究,以传统中药为基础,现代化学及药理研究为支撑,研究开发出安全、疗效显著、机制明确的中药复方,为抗肝纤维化治疗提供思路。At present,the anti fibrosis mechanism of TCM mainly includes:inhibiting the activation of hepatic stellate cells,reducing the damage of hepatic cells;inhibition of ECM synthesis and degradation;antioxidation,inhibition of inflammation and so on.But the research has the following shortcomings:the sample size of clinical observation is small,and there is a lack of unified treatment standard.The mechanism research is mainly based on animal experiments,but less on clinical experiments.The research is still immature.In the future,we need to further strengthen the basic and clinical research,expand the basic research concept,and conduct mechanism research from the aspects of intestinal flora and exosomes,carry out high-quality clinical research,based on TCM and supported by modern chemical and pharmacological research,research and develop safe,effective Chinese medicinal compound formulas with clear mechanism,so as to provide ideas for the treatment of hepatic fibrosis(HF).

关 键 词：肝纤维化 中医药 机制研究 文献综述 

分 类 号：R259[医药卫生—中西医结合]