聚焦网络药理学:黄芩苷治疗急性牙周炎的效应机制研究  

Mechanism of Baicalin in the Treatment of Acute Periodontitis Based on Network Pharmacology

作　　者：顾磊 廖维 周建萍[3] GU Lei;LIAO Wei;ZHOU Jianping(Department of Stomatology,Chongqing Fire Rescue Corps Hospital,Chongqing 401122,China;Department of Anesthesiology,Xinqiao Hospital,The Second Hospital Affiliated to Third Military Medical University;Orthodontics,Stomatological Hospital of Chongqing Medical University)

机构地区：[1]重庆市消防救援总队医院口腔科,重庆401122 [2]陆军医科大学附属第二医院新桥医院麻醉科 [3]重庆医科大学附属口腔医院正畸科

出　　处：《西部中医药》2021年第7期17-22,共6页Western Journal of Traditional Chinese Medicine

基　　金：重庆基础研究与前沿探索项目(重庆市自然科学基金)(cstc2018jcyjAX0220)。

摘　　要：目的:基于网络药理学方法,从系统层面探讨黄芩苷治疗急性牙周炎的潜在作用机制。方法:从NCBI pubchem和TCMSP获取黄芩苷的化合物信息,在NCBI数据库、Pharmmapper数据库获取黄芩苷的靶点,在DiseaseGene Network获取急性牙周炎的靶点,通过基因映射预测黄芩苷治疗急性牙周炎的潜在作用靶点,在STRING数据库建立黄芩苷治疗急性牙周炎的高置信度PPI网络。采用拓扑分析和富集分析获得黄芩苷治疗急性牙周炎的具有拓扑重要性的靶点及核心作用通路,及其涉及的生物过程、细胞成分及分子功能。结果:共获取黄芩苷的332个靶点及急性牙周炎的44个靶点,预测黄芩苷治疗急性牙周炎的13个潜在作用靶点,建立了黄芩苷治疗急性牙周炎的一个13个节点、38条边的高置信度PPI网络。获得了黄芩苷治疗急性牙周炎的6个具有拓扑重要性的靶点,4条核心作用通路,及其涉及的21个生物过程(BP)、3个细胞成分(CC)、2个分子功能(MF)。结论:黄芩苷治疗急性牙周炎的机制涉及多个靶点和信号通路,这些靶点与通路在调节炎症、凋亡以及其他与治疗急性牙周炎作用有关的生理病理过程有关。Objective:To explore the potential mechanism of baicalin in the treatment of acute periodontitis from system level based on network pharmacology.Methods:The compound information of baicalin was obtained from NCBI pubchem and TCMSP,the targets of baicalin were obtained from NCBI database and Pharmmapper database,the target of acute periodontitis was obtained from DiseaseGene Network,the potential target of baicalin in the treatment of acute periodontitis was predicted by gene mapping,and the high confidence PPI network of baicalin in the treatment of acute periodontitis was established in STRING database.Topological analysis and enrichment analysis were used to obtain the topologically important targets and core pathways of baicalin in the treatment of acute periodontitis,as well as the biological processes,cellular components and molecular functions involved.Results:A total of 332 targets of baicalin and 44 targets of acute periodontitis were obtained,13 potential targets of baicalin in the treatment of acute periodontitis were predicted,a high confidence PPI network with 13 nodes and 38 edges was established.Six topologically important targets,four core pathways,21 biological processes(BP),three cellular components(CC)and two molecular functions(MF)of baicalin in the treatment of acute periodontitis were gained.Conclusion:The mechanism of baicalin in the treatment of acute periodontitis involves multiple targets and signaling pathways,which are related to the regulation of inflammation,apoptosis and other physiological and pathological processes related to the treatment of acute periodontitis.

关 键 词：急性牙周炎 网络药理学 黄芩苷 

分 类 号：R276[医药卫生—中医五官科学]