基于中医药传承辅助平台分析治疗口腔扁平苔藓的方剂组方用药规律  

Medication Rules of the Prescriptions for the Treatment of Oral Lichen Planus Based on TCMISS

作　　者：王春 文跃强[1] 高彩铃 吴也可[2] 颜家渝[1,2,3] WANG Chun;WEN Yueqiang;GAO Cailing;WU Yeke;YAN Jiayu(Chengdu University of TCM,Chengdu 611137,China;Teaching Hospital of Chengdu University of TCM;Guang’an Hospital Affiliated to Chengdu University of TCM/Guang’an City Hospital of Traditional Chinese Medicine)

机构地区：[1]成都中医药大学,四川成都611137 [2]成都中医药大学附属医院 [3]成都中医药大学附属广安医院/广安市中医医院

出　　处：《西部中医药》2021年第7期64-67,共4页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年项目(81973684);四川省科技计划项目(18ZDYF0878);四川省学术和技术带头人培养支持经费资助项目(008061)。

摘　　要：目的:基于中医传承辅助平台(V2.5)软件分析治疗口腔扁平苔藓的方剂组方用药规律。方法:筛选CNKI、VIP、万方数据库中近5年治疗口腔扁平苔藓的方剂,通过中医传承辅助平台(V2.5)软件构建方剂数据库,利用该软件集成的关联规则及熵聚类等数据挖掘算法,进行用药频次、药物性味归经、常用药对分析,挖掘得到潜在药对和新方。结果:共收集治疗口腔扁平苔藓方剂146首,涉及中药229味,药物出现频次前15位的中药体现了湿、热(火)、瘀、毒互结的病机特点;药性以寒性为主,药味多偏甘苦;主要归脾、胃、肝经,其次在心、肾经。挖掘得到常用药对36个,潜在药对及新方21个。结论:近5年CNKI、VIP、万方数据库中收录的治疗口腔扁平苔藓方剂以清热滋阴、行气化瘀、利湿解毒、疏肝解郁、补气养血为主。Objective:To analyze the medication rules of the prescriptions for oral lichen planus(OLP)based on TCMISS(V2.5).Methods:The prescriptions of treating OLP were searched from CNKI,VIP and Wanfang databases in the recent five years,the database of prescriptions was established using TCMISS(V2.5),by using the data mining algorithms such as association rules and entropy clustering integrated by the software,medication frequency,the nature,flavor and entering meridians of the drugs and common drug pairs were analyzed to obtain the potential drug pairs and new prescription.Results:All 146 prescriptions for OLP were collected,involving 229 drugs,the top 15 drugs show the pathogenesis characteristics of dampness,heat(fire),blood stasis and toxin,The medicine is mainly cold in nature,and its taste is sweet and bitter;The entering meridian is spleen,stomach and liver,followed by heart and kidney.36 commonly-used drug pairs,21 potential drug pairs and new prescriptions were obtained.Conclusion:The prescriptions for OLP collected in CNKI,VIP and Wanfang databases in the recent five years mainly clear heat and nourish Yin,promote Qi and remove blood stasis,eliminate dampness and toxin,sooth liver and relieve depression,tonify Qi and nourish blood.

关 键 词：口腔扁平苔藓 中医药传承辅助平台 方剂 用药规律 

分 类 号：R276.8[医药卫生—中医五官科学]