对比分析乙型肝炎肝硬化与原发性胆汁性肝硬化患者的临床特点  

Clinical Characteristics of Patients with Hepatitis B Cirrhosis and Primary Biliary Cirrhosis

作　　者：张丽丽 赵凤娥 ZHANG Lili;ZHAO Feng'e(Iron Coal General Hospital of Liaoning Health Industry Group,Tieling 112700,China)

机构地区：[1]辽宁省健康产业集团铁煤总医院,辽宁铁岭112700

出　　处：《中国医药指南》2021年第19期71-72,75,共3页Guide of China Medicine

摘　　要：目的探讨原发性胆汁性肝硬化与乙型肝炎肝硬化患者的临床特点。方法统计本院2020年4月至2021年2月接收的50例原发性胆汁性肝硬化患者与72例乙型肝炎肝硬化患者临床资料,并准确记录试验室检查指标,包括白蛋白(ALB)、碱性磷酸酶(ALP)、血小板(PLT)及凝血酶原活动度(PTA),比较临床特点。结果在ALB、ALP、PLT及PTA方面,乙型肝炎肝硬化组水平较原发性胆汁性肝硬化组偏低,差异有统计学意义(P <0.05);在原发性肝癌及上消化道出血发生率方面,原发性胆汁性肝硬化组较乙型肝炎肝硬化组低,差异有统计学意义(P <0.05);在感染、自发性腹膜炎及肝性脑病发生率方面,原发性胆汁性肝硬化组与乙型肝炎肝硬化组相比,差异无统计学意义(P> 0.05)。结论相比于原发性胆汁性肝硬化患者,乙型肝炎肝硬化患者自身肝功能相对较差,很容易合并原发性肝癌及上消化道出血等,具有较高的并发症发生率,临床治疗期间,应根据患者具体临床特点提供相应的治疗方法,以便改善患者预后效果。Objective To investigate the clinical characteristics of patients with primary biliary cirrhosis and hepatitis B cirrhosis.Methods The clinical data of 50 patients with primary biliary cirrhosis and 72 patients with hepatitis B cirrhosis received in our hospital from April 2020 to February 2021 were analyzed.The laboratory examination indexes including albumin(ALB),alkaline phosphatase(ALP),platelet(PLT)and prothrombin activity(PTA)were recorded accurately.In addition,the clinical characteristics were compared.Results The levels of ALB,ALP,PLT and PTA in hepatitis B cirrhosis group were lower than those in primary biliary cirrhosis group,and the difference was statistically significant(P<0.05).The incidence of primary liver cancer and upper gastrointestinal bleeding in primary biliary cirrhosis group was lower than that in hepatitis B cirrhosis group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of infection,spontaneous peritonitis and hepatic encephalopathy between primary biliary cirrhosis group and hepatitis B cirrhosis group(P>0.05).Conclusion Compared with the patients with primary biliary cirrhosis,the patients with hepatitis B cirrhosis have relatively poor liver function.They are easy to merge with primary hepatocellular carcinoma and upper gastrointestinal hemorrhage,and have a high incidence of complications.During clinical treatment,appropriate treatment methods should be provided according to the specific clinical characteristics of patients,so as to improve the prognosis of patients.

关 键 词：原发性胆汁性肝硬化 乙型肝炎肝硬化 临床特点 

分 类 号：R657.31[医药卫生—外科学]