左西孟旦联合诺欣妥对急诊经皮冠脉介入治疗术后患者肾素、血管紧张素Ⅱ和心功能的影响  

Impacts of levosimendan combined with entresto on renin,angiotensinⅡand cardiac function in patients after emergency percutaneous coronary intervention

作　　者：魏峰[1] 郑若龙[1] 李伟章[1] 陈新军[1] 蒋文龙[1] 李健[1] 钱惠东[1] WEI Feng;ZHENG Ruolong;LI Weizhang;CHEN Xinjun;JIANG Wenlong;LI Jian;QIAN Huidong(Department of Cardiovascular Internal Medicine,the Jiangyin People's Hospital,Jiangsu,Jiangyin 214400,China)

机构地区：[1]江苏省江阴市人民医院心血管内科,江苏江阴214400

出　　处：《中国医药科学》2021年第13期72-75,共4页China Medicine And Pharmacy

摘　　要：目的观察左西孟旦联合诺欣妥对急诊经皮冠脉介入(PCI)治疗术后患者肾素、血管紧张素和心功能的影响。方法选择2018年1月至2020年6月在江阴市人民医院接受急诊PCI的急性心肌梗死(AMI)患者96例,随机分为对照组(n=48)和联合治疗组(n=48)。对照组术后给予左西孟旦治疗,联合治疗组在对照组基础上加用诺欣妥口服8周。在术后第10天和第8周时分别测定肾素、血管紧张素Ⅱ、左室舒张末容积(LVEDD)、左室射血分数(LVEF)、氨基末端脑钠肽前体(NT-proBNP)和6分钟步行试验(6MWT)。结果两组患者术后10 d比较肾素、血管紧张素Ⅱ、LVEDD、LVEF、NT-pro BNP和6 MWT比较,差异无统计学意义(P>0.05)。治疗8周后联合治疗组患者LVEF和6 MWT较对照组进一步升高,差异有统计学意义(P<0.05),肾素、血管紧张素Ⅱ、LVEDD、NT-proBNP水平进一步降低,差异有统计学意义(P<0.05)。结论对于急诊PCI术后合并心力衰竭患者,联合使用诺欣妥和左西孟旦体现出较好改善心功能作用,而且能够提高患者运动耐量,改善生活状态。Objective To observe the impacts of levosimendan combined with entresto on renin,angiotensin and cardiac function in patients after emergency percutaneous coronary intervention(PCI).Methods A total of 96 patients with acute mycardial infarction(AMI)undergoing emergency PCI in the Jiangyin People’s Hospital,from January 2018 to June 2020 were selected,and they were randomly divided into the control group(n=48)and the combined treatment group(n=48).The control group was treated with levosimendan after operation,while the combined treatment group was treated with entresto orally for 8 weeks on the basis of the control group.The levels of renin,angiotensinⅡ,left ventricular end diastolic dimension(LVEDD),left ventricular ejection fraction(LVEF),N terminal pro B type natriuretic peptide(NT-proBNP)and 6-minute walking test(6 MWT)were detected on the 10 th day and 8 th week after operation.Results After 10 days of operation,there were no statistically significant differences in renin,angiotensinⅡ,LVEDD,LVEF,NT-proBNP and 6 MWT between the two groups of patients(P>0.05).After 8 weeks of treatment,LVEF and 6 MWT in patients of the combined treatment group further increased compared with those in the control group,with statistically significant differences(P<0.05).The levels of renin,angiotensinⅡ,LVEDD and NT-proBNP further decreased,with statistically significant differences(P<0.05).Conclusion For patients with heart failure after emergency PCI,the combined use of entresto and levosimendan can boost cardiac function,increase exercise tolerance and improve the living condition.

关 键 词：左西孟旦 诺欣妥 急诊PCI 心力衰竭 

分 类 号：R541.4[医药卫生—心血管疾病]