哌拉西林钠舒巴坦钠治疗先天性心脏病婴儿肺炎的疗效观察  

Efficacy of Piperacillin Sodium and Sulbactam Sodium for Injection on infant pneumonia with congenital heart disease

作　　者：韩宏洋 HAN Hongyang(Internal Medicine 2,Shenyang Children's Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市儿童医院内二科,辽宁沈阳110000

出　　处：《中国医药指南》2021年第18期67-68,共2页Guide of China Medicine

摘　　要：目的研究哌拉西林钠舒巴坦钠对先天性心脏病婴儿肺炎的治疗效果。方法纳入100例患儿作为此次研究的对象,所有患儿均在我院确诊为先天性心脏病,并患有肺炎,患儿监护人均同意在我院接受治疗并在知情前提下参与本院此次研究,纳入时间段为2019年4月至2020年4月。以选择的治疗方法的不同作为分组依据,将患儿按照人数1∶1的比例分为两个组别,即对照组和观察组。两组患儿均接受常规治疗,对照组患儿在常规治疗基础上以注射用拉氧头孢进行临床治疗,观察组患儿在常规治疗基础上以注射用哌拉西林钠舒巴坦钠进行临床治疗,对比两组患儿的治疗效果,并统计患儿治疗前后的心率(HR)、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))水平进行对比。结果对照组中,39例患儿的治疗效果评价为显效和有效,11例为无效,总有效率为78.00%,观察组中,49例患儿的治疗效果评价为显效和有效,1例为无效,总有效率为98.00%,组间差异显著(P<0.05);在临床实施之前,两组患儿的HR、PaO_(2)、PaCO_(2)水平没有显著差异(P>0.05),治疗结束之后,两组患儿的水平均有显著改变,组间统计学对比结果显示,观察组患儿的改善效果显著优于对照组患儿,组间差异显著(P<0.05)。结论哌拉西林钠舒巴坦钠治疗先天性心脏病合并患有肺炎的患儿有较好的治疗效果,可有效改善患儿的HR、PaO_(2)、PaCO_(2)水平。Objective To study the effect of piperacillin sodium and sulbactam sodium for injection on pneumonia with congenital heart disease.Methods One hundred children were included as the subjects of this study,and all the children were diagnosed with congenital heart disease and pneumonia in our hospital.The guardians of the children agreed to accept treatment and knowingly participate in the study.The included time period was from April 2019 to April 2020.The difference of the selected treatments as the group basis,the children were divided into two groups according to the proportion of 1∶1,namely the control group and the observation group.Both groups were given routine treatment.Children in the control group were treated with laoxycephalosporin for injection on the basis of conventional treatment,and children in the observation group were treated with piperacillin sodium and sulbactam sodium for injection on the basis of conventional treatment,compared the treatment effect of the two groups,and the levels of heart rate(HR),arterial blood oxygen pressure(PaO_(2))and arterial partial pressure of carbon dioxide(PaCO_(2))were compared.Results In the control group,the treatment effect of 39 children was evaluated as effective and effective,11 cases are invalid,total efficiency is 78.00%,in the observation group,the treatment of 49 children was evaluated as effective and effective,the 1 case is invalid,total efficiency is 98.00%,significant differences between groups(P<0.05);Prior to the clinical implementation,there were no significant differences in HR,PaO_(2),and PaCO_(2) levels in the two groups(P>0.05),after the treatment has ended,the levels have changed significantly in both groups,intergroup statistical comparison results show that,the improvement effect in the observation group was significantly better than that in the control group,intergroup differences were significant(P<0.05).Conclusion Piperacillin sodium and sulbactam sodium for injection has a good therapeutic effect in the treatment of children with con

关 键 词：哌拉西林钠舒巴坦钠 先天性心脏病 小儿肺炎 治疗效果 

分 类 号：R725.4[医药卫生—儿科] R725.6[医药卫生—临床医学]