新三联用药治疗宫缩乏力性产后出血40例的临床研究  

Clinical Study on New Three-drug Therapy in the Treatment of 40 Cases of Postpartum Hemorrhage due to Uterine Inertia

作　　者：熊庆庆 付勇辉 柳婷[1] 何凤 李玉巧 罗权[1] XIONG Qingqing;FU Yonghui;LIU Ting;HE Feng;LI Yuqiao;LUO Quan(Jiujiang Maternal and Child Health Hospital,Jiujiang Jiangxi 332000,China.)

机构地区：[1]九江市妇幼保健院,江西九江332000

出　　处：《药品评价》2021年第11期683-685,共3页Drug Evaluation

基　　金：江西省卫生健康委科技计划(20204240)

摘　　要：目的:探讨新三联用药治疗宫缩乏力性产后出血的临床应用价值。方法:选取2018年8月至2020年8月于九江市妇幼保健院接受治疗的80例宫缩乏力性产后出血患者,依据掷硬币法分为对照组(n=40)与试验组(n=40)。对照组采用卡前列素氨丁三醇治疗,试验组采用新三联用药治疗,即在对照组基础上加用葡萄糖酸钙和卡前列甲酯栓治疗,连续治疗24 h;治疗结束后,比较两组临床疗效、出血情况;比较两组治疗前、治疗24 h后一氧化氮(NO)和脑钠肽(BNP)水平;比较两组不良反应发生情况。结果:试验组总有效率97.50%高于对照组80.00%,产后2 h出血量、产后24 h出血量均低于对照组,止血时间短于对照组(P<0.05);治疗24 h后,两组NO和BNP水平均低于治疗前,且试验组低于对照组(P<0.05);试验组与对照组均未出现不良反应。结论:宫缩乏力性产后出血患者采用新三联用药治疗效果显著,可有效改善NO、BNP水平,且未增加不良反应,具有较高的安全性。Objective:To explore the clinical application value of new three-drug therapy in the treatment of postpartum hemorrhage due to uterine inertia.Methods:80 patients with postpartum hemorrhage due to uterine inertia who recieved treatment in Jiujiang Maternal and Child Health Hospital from August 2018 to August 2020 were selected,the coin toss method was used to divide them into a control group(n=40)and an experimental group(n=40).The control group was treated with carboprost tromethamine,the experimental group was treated with new three-drug therapy,namely added calcium gluconate and carboprost suppository on the basis of the control group,both were continuous treated for 24 hours;after treatment,the clinical efficacy and bleeding condition of the two groups were compared;the levels of nitric oxide(NO)and brain natriuretic peptide(BNP)were compared between the two groups before and after 24 hours of treatment;the incidence of adverse reactions between the two groups was counted and compared.Results:The total effective rate of the experimental group was 97.50%,higher than 80.00%of the control group,the bleeding volume 2 hours and 24 hours after delivery in the experimental group were lower than the control group,and the hemostasis time was shorter than the control group(P<0.05);after 24 hours of treatment,the levels of NO and BNP in both groups were lower than those before treatment,and the experimental group were lower than the control group(P<0.05);there were no adverse reactions in the experimental group and the control group.Conclusion:The new three-drug therapy has significant effect in the treatment of patients with postpartum hemorrhage due to uterine inertia,improve the level of NO and BNP,and will not increase adverse reactions,has relatively high safety.

关 键 词：宫缩乏力 产后出血 卡前列素氨丁三醇 醋酸钙 卡前列甲酯栓 出血情况 

分 类 号：R714.461[医药卫生—妇产科学]