稳定期白癜风患者组织液sICAM-1水平与临床特征的相关性分析  

Correlation Analysis between the sICAM-1 in the Skin Tissue Fluid with Stable Vitiligo and Clinical Characteristics

作　　者：杨雪松[1] 付彧[2] 毛慧玲[3] 颜令义[1] 房庆华[1] 哈达[1] 吕晓红[1] 刘灵[1] 陶宇 YANG Xue-song;FU Yu;MAO Hui-ling;YAN Ling-yi;FANG Qing-hua;HA Da;LVXiao-hong;LIU Ling;TAO Yu(Department of Dermatology,Daqing Longnan Hospital,the Fifth Affiliated Hospital of Qiqihar Medical University,Daqing 163453,Heilongjiang,China;Department of General Surgery,Daqing Oilfield General Hospital,Daqing 163001,Heilongjiang,China;Department of Science and Technology Management,Daqing Longnan Hospital,the Fifth Affiliated Hospital of Qiqihar Medical University,Daqing 163453,Heilongjiang,China)

机构地区：[1]齐齐哈尔医学院第五附属医院大庆龙南医院皮肤科,黑龙江大庆163453 [2]大庆油田总医院普外科,黑龙江大庆163001 [3]齐齐哈尔医学院第五附属医院大庆龙南医院科技管理科,黑龙江大庆163453

出　　处：《中国美容医学》2021年第6期83-86,共4页Chinese Journal of Aesthetic Medicine

基　　金：黑龙江省卫生健康委科研课题(名称:白癜风细胞因子与病程和皮损面积间的相关性分析,编号:2019-377)。

摘　　要：目的:探究稳定期白癜风患者皮肤组织液sICAM-1水平的表达变化及与临床特征的关联性。方法:选择30例笔者医院收治确诊的稳定期白癜风患者为研究对象,其中寻常型20例,节段型10例,采用酶联免疫吸附法(ELISA)对白斑处和非白斑处皮肤组织液中的sICAM-1水平进行对比分析,并由专人记录患者的临床特征。结果:对稳定期白癜风患者的皮肤组织液sICAM-1水平进行检测:①寻常型白斑处sICAM-1水平明显高于非白斑处(P<0.05),且高于节段型(P<0.05);②白斑处sICAM-1水平与病程呈负相关性(P<0.05),寻常型和节段型白斑处sICAM-1水平与病程均呈负相关性(P<0.05);③白斑处sICAM-1水平与皮损面积呈正相关性(P<0.05);④节段型白斑处sICAM-1水平与年龄呈负相关性(P<0.05);⑤寻常型皮损面积大于节段型(P<0.05)。结论:稳定期白癜风患者白斑处皮肤组织液中sICAM-1水平表达异常,且与患者病程和皮损面积有关。Objective The correlation analysis between the sICAM-1 in the skin tissue fluid with stable vitiligo and clinical characteristics were investigated.Methods Selected 30 patients with stable vitiligo,including 20 patients with vitiligo vulgaris and 10 patients with segmental vitiligo.The levels of sICAM-1 in the skin tissue fluid at white spots and non-white spots were compared and analyzed by enzyme-linked immunosorbent assay(ELISA).The patient’s clinical characteristics were recorded by the same person.Results The levels of sICAM-1 in the skin tissue fluid with stable vitiligo were detected:①The levels of sICAM-1 in the white spots with vitiligo vulgaris was significantly higher than that in the non-white spots(P<0.05),and higher than that with segmental vitiligo(P<0.05).②There was a negative correlation between the levels of sICAM-1 and course of disease in white spots(P<0.05).There was a negative correlation between the levels of sICAM-1 and course of disease in white spots with vitiligo vulgaris(P<0.05).There was a negative correlation between the levels of sICAM-1 and course of disease in white spots with segmental vitiligo(P<0.05).③There was a positive correlation between the levels of sICAM-1 and lesion area in white spots(P<0.05).④There was a negative correlation between the levels of sICAM-1 and age in white spots with segmental vitiligo(P<0.05).⑤The lesion area of vitiligo vulgaris was larger than that of segmental vitiligo(P<0.05).Conclusion The expression of sICAM-1 in the skin tissue fluid with stable vitiligo was abnormal,which was related to the course of disease and lesion area.

关 键 词：白癜风 可溶性细胞间黏附分子-1 病程 皮损面积 年龄 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]