骨质疏松症基因多态性的研究进展  

Research progress on gene polymorphism in osteoporosis

作　　者：张帆 熊燕红 韩超 梁清洋 刘佳[1] 唐毓金[1] ZHANG Fan;XIONG Yanhong;HAN Chao;LIANG Qingyang;LIU Jia;TANG Yujin(Department of Orthopedics,Affiliated Hospital of Youjiang Medical University for Nationalities,Guangxi Zhuang Autonomous Region,Baise 533000,China;Department of Gynecology,Affiliated Hospital of Youjiang Medical University for Nationalities,Guangxi Zhuang Autonomous Region,Baise 533000,China)

机构地区：[1]右江民族医学院附属医院脊柱骨科,广西百色533000 [2]右江民族医学院附属医院妇科,广西百色533000

出　　处：《中国医药导报》2021年第19期56-59,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81260315)。

摘　　要：本文总结了目前基因多态性对骨质疏松症的影响。维生素D受体基因突变会改变矿物质的代谢,使骨密度降低;雌激素受体基因同一位点对不同种族、不同性别的影响可能存在差异;Ⅰ型胶原基因可加重心血管疾病患者的骨质疏松症;Gremlin-2基因的不同位点对骨质疏松症的效果可能相反;肿瘤坏死因子-α基因、护骨因子基因的基因-基因联合效应都可能造成骨质疏松症风险增加。以上研究结果均表明基因多态性对骨质疏松症中具有独特作用,并可能提供针对性治疗来避免骨骼退变。This paper summarizes the effects of gene polymorphism in osteoporosis.Mutations in the vitamin D receptor gene alter mineral metabolism and lead to lower bone density.The effects of the same locus of estrogen receptor gene on different races and genders may be different.Collagen typeⅠgene can aggravate osteoporosis in patients with cardiovascular disease.Different loci of the Gremlin-2 gene may have opposite effects on osteoporosis.The combined gene-gene effect of tumor necrosis factor-αgene and osteoprotegerin gene may increase the risk of osteoporosis.These results suggest that gene polymorphism plays a unique role in osteoporosis,and may provide targeted treatment to avoid bone degeneration.

关 键 词：骨质疏松症 基因多态性 维生素D受体基因 雌激素受体基因 Ⅰ型胶原基因 肿瘤坏死因子-Α基因 

分 类 号：R589[医药卫生—内分泌]