甜菜碱改善肥胖及相关代谢紊乱作用机制的研究进展  

Research progress in the mechanism of betaine in reducing obesity and related metabolic disorders

作　　者：安冬[1] 杨军红[1] 宋晓萌[2] AN Dong;YANG Jun-hong;SONG Xiao-meng(Tianjin Children's Hospital,Tianjin 300134;Tianjin Medical University,Tianjin 300070)

机构地区：[1]天津市儿童医院(天津大学儿童医院),天津300134 [2]天津医科大学,天津300070

出　　处：《中南药学》2021年第7期1393-1398,共6页Central South Pharmacy

基　　金：天津市教委科研计划项目(No.2018KJ076)。

摘　　要：甜菜碱是一种天然无毒的膳食营养素,作为渗透压保护剂及甲基供体发挥生理作用,目前被应用于非酒精性脂肪肝、心血管疾病、2型糖尿病、癌症等疾病的治疗。研究发现甜菜碱能增加肥胖患者的瘦体重,降低体脂率,改善体成分,降低脂肪组织炎症水平及改善肥胖相关代谢紊乱。其可能的机制包括改善脂肪酸代谢、增加蛋白质合成、降低脂肪组织炎症反应以及改善胰岛素抵抗等。Betaine is a natural,non-toxic dietary nutrient that physiologically serves as an osmotic pressure protector and methyl donor.It is currently used for non-fatty liver diseases,cardiovascular diseases,type 2 diabetes,cancer and other diseases.Research found that betaine increased lean body weight,reduced body fat rate,improved body composition,reduced inflammation level of adipose tissue and improved obesity-related metabolic disorders in obese patients.The possible mechanism included improving fat metabolism,increasing protein synthesis,reducing inflammation of adipose tissue,and improving insulin resistance etc.

关 键 词：甜菜碱 肥胖 脂肪酸 炎症 胰岛素抵抗 

分 类 号：R96[医药卫生—药理学]