穴位贴敷组方治疗痰热郁肺型急性加重期慢性阻塞性肺疾病的临床观察  

Clinical Observation on Treating Acute Exacerbation Chronic Obstructive Pulmonary Disease of Phlegm Heat Stagnation Lung Type With Acupoint Application

作　　者：卢军仪 赵丹 孙义田[1] 李亚 LU Jun-yi;ZHAO Dan;SUN Yi-tian;LI Ya(Department of Geriatrics,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou Hebei 061000)

机构地区：[1]沧州中西医结合医院老年病科,河北沧州061000

出　　处：《世界中西医结合杂志》2021年第7期1324-1328,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局科研计划项目(3601014)。

摘　　要：目的观察穴位贴敷组方治疗急性加重期慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)(痰热郁肺证)的疗效。方法将120例急性加重期COPD(痰热郁肺证)患者按照随机数字表法分为对照组60例与治疗组60例。明确急性加重期病因与病情严重程度后,对照组给予常规西医治疗,治疗组在西医治疗基础上联合穴位贴敷组方治疗,两组均连续治疗10 d。对比两组患者中医证候疗效、治疗安全性,治疗前后肺功能[第1 s用力呼气量占预计百分比(Percentage of forced expiratory volume in the first second,FEV 1%)、第1 s用力呼气量占用力肺活量百分比(Percentage of forced expiratory volume/Percentage of forced vital capacity in the first second,FEV 1/FVC)]、血气分析指标[氧合指数(Partial pressure of blood oxygen/Fraction of inspiration oxygen,PaO 2/FiO 2)、二氧化碳分压(Partial pressure of carbon dioxide,PaCO 2)、血氧分压(Partial pressure of blood oxygen,PaO 2)]及生活质量(COPD assessment test,CAT)评分改善情况。结果治疗组中医证候总有效率较对照组高,差异有统计学意义(P<0.05);治疗后两组患者FEV 1%、FEV 1/FVC均较本组治疗前升高,且治疗组较对照组高,差异有统计学意义(P<0.05);血气分析:治疗后两组患者PaO 2/FiO 2、PaCO 2、PaO 2水平均较本组治疗前改善,且治疗组PaO 2/FiO 2、PaO 2较对照组高,PaCO 2较对照组低,差异有统计学意义(P<0.05);治疗后两组患者CAT各维度评分及总分均较治疗前降低,且治疗组较对照组低,差异有统计学意义(P<0.05);安全性:治疗期间,两组患者均未发生严重并发症与不良反应,仅治疗组出现1例因药物贴敷引起局部皮红现象,未给予特殊干预自行消退,未影响治疗进展。结论穴位贴敷组方治疗急性加重期COPD安全、有效,可有效提高患者肺功能、改善血气分析及生活质量。Objective To explore the therapeutic effect of acupoint application prescription in acute exacerbation of COPD(phlegm-heat stagnation of lung syndrome).Methods 120 patients with acute exacerbation COPD(phlegm-heat stagnation of lung syndrome)were divided into control group(60 cases)and treatment group(60 cases)according to random number table method.After defining the cause and severity of acute exacerbation,the control group was given conventional western medicine treatment,and the treatment group was treated with acupoint sticking on the basis of Western medicine treatment.Both groups were treated continuously for 10 days.The curative effect and treatment safety of TCM syndromes in the two groups were compared,and the improvement of pulmonary function[FEV 1%,FEV 1/FVC],blood gas analysis indexes[oxygenation index(PaO 2/FiO 2),partial pressure of carbon dioxide(PaCO 2),partial pressure of oxygen in blood(PaO 2)]and quality of life(CAT)score before and after treatment were compared.Results The total effective rate of TCM syndromes in the treatment group was higher than that in the control group(P<0.05),and the difference was statistically significant.After treatment,the FEV 1%and FEV 1/FVC of the two groups were higher than those before the treatment,and the treatment group was higher than the control group.High(P<0.05),the difference is statistically significant;blood gas analysis:After treatment,the PaO 2/FiO 2,PaCO 2,and PaO 2 levels in the two groups improved compared with those before the treatment,and the PaO 2/FiO 2 and PaO 2 in the treatment group were higher than those in the control group,PaCO 2 It was lower than the control group(P<0.05),and the difference was statistically significant.After treatment,the scores and total scores of each CAT dimension in the two groups were lower than before treatment,and the treatment group was lower than the control group(P<0.05),the difference was statistically significant Significance;safety:during the treatment,no serious complications and adverse reactions occurre

关 键 词：慢性阻塞性肺疾病 急性加重期 穴位贴敷组方 肺功能 血气分析 生活质量 

分 类 号：R563.9[医药卫生—呼吸系统]