高密度脂蛋白胆固醇参考值对地理环境的岭回归分析  

Ridge Regression Analysis of the Reference Values of High Density Lipoprotein Cholesterol to the Geographical Environment

作　　者：葛淼 赵彤 杨帆 杨文婕 GE Miao;ZHAO Tong;YANG Fan;YANG Wen-jie(School of Geography and Tourism,Shaanxi Normal University,Xi'an 710119,China)

机构地区：[1]陕西师范大学地理科学与旅游学院,西安710119

出　　处：《西安文理学院学报（自然科学版）》2021年第3期36-43,共8页Journal of Xi’an University(Natural Science Edition)

基　　金：陕西省自然科学基础研究计划项目(2019JM-408);国家自然科学基金资助项目(40971060)。

摘　　要：搜索采集了分布于全国各地的152个县市级医院及有关科研单位测定的83942例健康成年人HDL-C参考值数据,再选取18项地理环境指标与搜集到的健康成年人HDL-C数据进行相关性分析,明确了与HDL-C参考值显著相关的地理环境因素,采取岭回归分析方法构建预测模型,再通过地统计分析方法得到健康成年人HDL-C参考值的空间分布图.结果发现,中国健康成年人HDL-C参考值与T_CaSO_(4)、表土碱度、表土盐分这3项地理环境因素之间存在显著相关,中国健康成年人HDL-C参考值的最优回归模型为Y=1.334+0.06533X_(16)-0.0005800X_(17)+0.1048X_(18)±0.1319.通过全国分布图可看出,空间上中国健康成年人HDL-C参考值呈现出西北地区水平高,东部及西南部地区水平浓度较低.若已知某一地区的这3项地理环境因素数据,即可利用该岭回归模型对健康成年人HDL-C参考值进行计算预测,对提高临床诊断和健康评估的准确性有明显促进作用.The data of 83942 healthy adults’HDL-C reference values measured by 152 county and municipal hospitals and relevant scientific research institutions were searched and collected.Then 18 geographical environment indexes and the collected HDL-C data of healthy adults were selected for correlation analysis.The geographical environment factors significantly related to HDL-C reference values were identified,and the ridge regression analysis method was used to build the prediction model,The spatial distribution of HDL-C reference value of healthy adults was obtained by geostatistical analysis.The results showed that there was a significant correlation between the reference value of HDL-C of Chinese healthy adults and three geographical factors such as T_CaSO_(4),surface soil alkalinity,surface soil salinity,etc.The optimal regression model of HDL-C reference value for Chinese healthy adults is Y=1.334+0.06533X_(16)-0.0005800X_(17)+0.1048X_(18)±0.1319.According to the national distribution map,the reference value of HDL-C of healthy adults in China is higher in the northwest,and lower in the east and southwest.If the data of these three geographical factors in a certain area are known,the ridge regression model can be used to calculate and predict the reference value of HDL-C for healthy adults,which can significantly promote the accuracy of clinical diagnosis and health assessment.

关 键 词：高密度脂蛋白胆固醇(HDL-C) 岭回归 地理环境 

分 类 号：Q548.1[生物学—生物化学] K909[历史地理—人文地理学]