PCT HMGB1与NAP在急性胆道系统感染中的作用探讨  

To explore the value of PCT,HMGB1 and NAP in acute biliary infection

作　　者：张开华[1] 刘奇盛 段新星[1] Zhang Kaihua;Liu Qisheng;Duan Xinxing(The First People's Hospital of Jiujiang City,Jiujiang,Jiangxi 332000)

机构地区：[1]九江市第一人民医院,江西九江332000

出　　处：《基层医学论坛》2021年第22期3114-3116,共3页The Medical Forum

基　　金：江西省卫生健康委科技计划(20202041)。

摘　　要：目的分析血清降钙素原(PCT)、血清高迁移率族蛋白B1(HMGB1)与中性粒细胞碱性磷酸酶(NAP)在急性胆道系统感染(ABTI)中的作用。方法前瞻性选取2018年3月—2020年4月九江市第一人民医院轻度、中度、重度ABTI患者各20例,均于入院时、治疗3 d、停药7 d时检测血清PCT、HMGB1与NAP水平,同时收集患者的细菌培养结果,分析血清PCT、HMGB1与NAP水平与细菌培养结果、重度感染的相关性。结果与入院时比较,60例患者治疗3 d、停药7 d时血清PCT、HMGB1水平与NAP阳性率逐渐降低,差异均有统计学意义(P<0.05);入院时,重度ABTI患者血清PCT、HMGB1水平与NAP阳性率均高于轻度、中度ABTI患者,差异有统计学意义(P<0.05);经Logistics回归分析结果显示,血清PCT、HMGB1水平与NAP阳性率高与重度感染有关(OR>1,P<0.05)。经细菌培养确诊,60例患者中细菌感染35例,病毒感染25例;细菌感染患者NAP阳性率、PCT水平均高于病毒感染患者,差异有统计学意义(P<0.05);经Logistics回归分析结果显示,血清PCT水平与NAP阳性率高与细菌感染有关(OR>1,P<0.05)。结论血清PCT、HMGB1与NAP在ABTI中有较高的应用价值,不仅能够有效预测患者病情严重度,还可判断ABTI感染类型。Objective To analyze the effects of serum procalcitonin(PCT),serum high mobility group protein B1(HMGB1)and neutrophil alkaline phosphatase(NAP)in acute biliary infection(ABTI).Methods Prospectively select 20 patients with mild,moderate and severe ABTI in our hospital from March 2018 to April 2020.Serum PCT,HMGB1 and NAP levels were detected on admission,3 days of treatment,and 7 days of drug withdrawal.At the same time Collect the results of bacterial culture of patients,and analyze the correlation of serum PCT,HMGB1 and NAP levels with bacterial culture results and severe infections.Results The serum PCT and HMGB1 levels and the NAP positive rate of 60 patients were gradually reduced at 3 days of treatment and 7 days after drug withdrawal,and the difference was statistically significant(P<0.05).At admission,serum PCT and HMGB1 of patients with severe ABTI The positive rate of NAP level and NAP were higher than those of mild and moderate ABTI patients,and the difference was statistically significant(P<0.05).The logistic regression analysis showed that the high serum PCT and HMGB1 levels and the positive rate of NAP were related to severe infection(OR>1,P<0.05);confirmed by bacterial culture,among the 60 patients,35 were bacterial infections and 25 were viral infections;the NAP positive rate and PCT levels of bacterial infection patients were higher than those of viral infections,and the difference was statistically significant(P<0.05);Logistics regression analysis showed that the high serum PCT level and NAP positive rate were related to bacterial infection(OR>1,P<0.05).Conclusion Serum PCT,HMGB1 and NAP have high value in ABTI,which can not only effectively predict the severity of the patient’s condition,but also determine the type of ABTI infection.

关 键 词：急性胆道系统感染 降钙素原 血清高迁移率族蛋白B1 中性粒细胞碱性磷酸酶 

分 类 号：R4[医药卫生—临床医学]