Single-sweep volumetric optoacoustictomography of whole mice  

作　　者：SANDEEP KUMAR KALVA XOSE LUIS DEAN-BEN DANIEL RAZANSKY 

机构地区：[1]Institute of Pharmacology and Toxicology and Institute for Biomedical Engineering,Faculty of Medicine,University of Zurich,Zurich,Switzerland [2]Institute for Biomedical Engineering,Department of Information Technology and Electrical Engineering,ETH Zurich,Zurich,Switzerland

出　　处：《Photonics Research》2021年第6期899-908,共10页光子学研究（英文版）

基　　金：European Research Council(ERC-2015-CoG-682379).

摘　　要：Applicability of optoacoustic imaging in biology and medicine is determined by several key performance characteristics.In particular,an inherent trade-off exists between the acquired field-of-view(FOV)and temporal resolution of the measurements,which may hinder studies looking at rapid biodynamics at the whole-body level.Here,we report on a single-sweep volumetric optoacoustic tomography(sSVOT)system that attains whole body three-dimensional mouse scans within 1.8 s with better than 200μm spatial resolution.sSVOT employs a spherical matrix array transducer in combination with multibeam illumination,the latter playing a critical role in maximizing the effective FOV and imaging speed performance.The system further takes advantage of the spatial response of the individual ultrasound detection elements to mitigate common image artifacts related to limited-view tomographic geometry,thus enabling rapid acquisitions without compromising image quality and contrast.We compare performance metrics to the previously reported whole-body mouse imaging implementations and alternative image compounding and reconstruction strategies.It is anticipated that sSVOT will open new venues for studying large-scale biodynamics,such as accumulation and clearance of molecular agents and drugs across multiple organs,circulation of cells,and functional responses to stimuli.

关 键 词：IMAGE latter ILLUMINATION 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术] R318[自动化与计算机技术—计算机科学与技术]