类氨基酸基载药水凝胶敷料的制备与性能  

Preparation and properties of amino acid based drug loaded hydrogel dressing

作　　者：周天扬 张数鹏 周诗绚 施冬健 陈明清 ZHOU Tianyang;ZHANG Shupeng;ZHOU Shixuan;SHI Dongjian;CHEN Mingqing(Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,School of Chemical and Material Engineering Jiangnan University,Wuxi 214122,Jiangsu,China)

机构地区：[1]江南大学化学与材料工程学院,合成与生物胶体教育部重点实验室,江苏无锡214122

出　　处：《精细化工》2021年第7期1393-1401,共9页Fine Chemicals

摘　　要：为制备一种具有良好生物相容性、可控缓释的物理交联的水凝胶敷料,选用类氨基酸单体N-丙烯酰基甘氨酰胺(NAGA)与生物发酵产物衣康酸(IA)为单体,在紫外光(254nm)下,通过自由基聚合,在不需要外加任何交联剂条件下即可形成水凝胶聚(N-丙烯酰基甘氨酰胺-衣康酸)[P(NAGA-IA)]。其中,由NAGA与IA物质的量比为20.0∶1制备的水凝胶P(NAGA20-IA1)具有pH响应性、溶胶-凝胶转变温度、较高的水溶胀率(40倍)及力学性能(压缩模量最高540 kPa)、较优的药物负载性和缓释性,NAGA单元提供的分子间多重氢键作用赋予了水凝胶较优的综合性能;而IA单元赋予了聚合物的pH刺激响应性,从而可诱导药物的释放。因此,所得P(NAGA-IA)水凝胶可作敷料用于创伤治疗。In order to prepare a physical cross-linked hydrogel dressing with good biocompatibility and controllable drug release,hydrogel poly(N-acryloylglycine-itaconic acid)[P(NAGA-IA)]was prepared by radical polymerization between amino acid monomer N-acryl glycine amide(NAGA)and biological fermentation product itaconic acid(IA)under ultraviolet light(254 nm)without addition of crosslinking agent.The obtained hydrogel showed lower sol-gel transition temperature,higher water swelling(40-fold)and mechanical properties(540 kPa of maximum compression modulus),and better drug loading and release.This was attributed to that NAGA units provided multiple hydrogen bonding between molecules,which endows hydrogels with better comprehensive properties.Moreover,IA units provided pH stimuli responsive property,which can induce drug release.Therefore,the P(NAGA-IA)hydrogel could be used as wound dressing for wound healing.

关 键 词：N-丙烯酰基甘氨酰胺 衣康酸 物理交联水凝胶 医用敷料 功能材料 

分 类 号：TQ460.4[化学工程—制药化工] TQ427.2