循环外泌体微小RNA:动脉粥样硬化性心血管疾病新型标志物  

Research advances on circulating exosomal microRNAs as novel biomarkers of atherosclerotic cardiovascular diseases

作　　者：吴嘉 汪俊军 Wu Jia;Wang Junjun(Department of Clinical Laboratory,Eastern Theater General Hospital of PLA,Nanjing 210002,China)

机构地区：[1]解放军东部战区总医院检验科,南京210002

出　　处：《中华检验医学杂志》2021年第7期558-562,共5页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(81572074,81871702)。

摘　　要：心血管系统不同来源的外泌体微小RNA(miRNA)参与调控血管生成、心肌重塑、炎症反应、斑块破裂等过程,并有望成为动脉粥样硬化性心血管疾病(ASCVD)新型液体活检标志物,可评估与监测ASCVD病情进展,具有作为ASCVD疗效监控新靶标的潜能。该文阐述近年来外泌体miRNA在ASCVD检验医学领域的最新研究,并对循环外泌体miRNA研究趋势及应用前景进行了展望。Exosomal microRNAs(miRNAs)from various cell sources in the cardiovascular system are involved in the regulation of diverse biological processes such as angiogenesis,myocardial remodeling,inflammation and plaque rupture,and may function as promising liquid biomarkers for atherosclerotic cardiovascular diseases(ASCVD).Expression analysis of exosomal miRNAs can be employed for monitoring ASCVD progression and evaluating treatment efficiency.This review focused on recent research advances regarding exosomal miRNAs in the field of ASCVD laboratory medicine,and summarized the future research trends and application prospects of circulating exosomal miRNAs in the field of ASCVD.

关 键 词：外泌体 微小RNA 动脉粥样硬化 生物学标记 

分 类 号：R54[医药卫生—心血管疾病]